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  1. Prevention of type 1 diabetes from laboratory to public health.

    Article - En anglais

    Despite recent progress in immunology and genetics, the causes of type 1 diabetes remain unknown.

    Prevention of autoimmune diseases through immunomodulation or gene therapy has not yet been successful in humans.

    In contrast, some autoimmune diseases such as celiac disease, rheumatic fever, and congenital rubella induced diabetes can be avoided through modification of environmental factors.

    Candidate environmental causes of type 1 diabetes are now being characterized in cohort studies and clinical trials.

    An alternative approach to prevention of type 1 diabetes may include a « vaccination » in early childhood to induce tolerance to critical autoantigen (s).

    This paper reviews the status of current diabetes prevention trials in humans and selected new interventions that are being tested in animal models.

    We estimate the cost of public health implementation of selected screening and intervention scenarios.

    The ethical, logistic, and funding issues underlying these scenarios are discussed.

    Mots-clés Pascal : Diabète insulinodépendant, Prévention, Dépistage, Stade précoce, Marqueur génétique, Marqueur biologique, Système HLA-DR, Antigène histocompatibilité classe II, Anticorps, Autoanticorps, Facteur risque, Insuline, Traitement, Immunothérapie, Tolérance immune, Chimiothérapie, Nicotinamide, Environnement, Economie santé, Coût, Système HLA, Homme, Endocrinopathie, Immunopathologie, Maladie autoimmune, Hormone pancréatique, Hormone protéine

    Mots-clés Pascal anglais : Insulin dependent diabetes, Prevention, Medical screening, Early stage, Genetic marker, Biological marker, HLA-DR-System, Class II histocompatibility antigen, Antibody, Autoantibody, Risk factor, Insulin, Treatment, Immunotherapy, Immune tolerance, Chemotherapy, Nicotinamide, Environment, Health economy, Costs, HLA-System, Human, Endocrinopathy, Immunopathology, Autoimmune disease, Pancreatic hormone, Protein hormone

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0257384

    Code Inist : 002B21E01A. Création : 16/11/1999.