During the past few years, the incidence of invasive group A Streptococcus (GAS) infection has been increasing.
However, there are presently no clear recommendations regarding antibiotic prophylaxis for close contacts of index patients.
The aims of this study were 1) to determine the prevalence of carriage of the same GAS strain as the patient's among contacts of patients with invasive infections and 2) to assess the importance of exposure duration.
From March 1995 to March 1996, the authors prospectively included in the study all patients with invasive GAS infection, as defined by the Working Group on Severe Streptococcal Infections, who came to Hôpital Maisonneuve-Rosemont in Montreal, Quebec, Canada.
An epidemiologic investigation was systematically carried out for each index case.
Contacts were divided into two groups : those who had spent 24 hours or more with the index patient during the week preceding the beginning of his or her illness and those who had spent 12-24 hours with the index patient during that week.
Strains of GAS were examined by serotyping (proteins M and T and the presence or absence of the serum opacity factor) and by characterization of streptococcal pyrogenic exotoxins (exotoxins A, B, and C).
One hundred and two contacts of 17 index cases with invasive GAS infection were systematically screened.
Contacts were considered positive if they carried the same strain of the bacterium and the same streptococcal pyrogenic exotoxin as the index case. (...)
Mots-clés Pascal : Infection, Maladie contagieuse, Transmission, Streptococcus A, Streptococcaceae, Micrococcales, Bactérie, Prévalence, Durée, Contact, Epidémiologie, Facteur risque, Homme, Québec, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Infection, Communicable disease, Transmission, Streptococcus A, Streptococcaceae, Micrococcales, Bacteria, Prevalence, Duration, Contact, Epidemiology, Risk factor, Human, Quebec, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0255051
Code Inist : 002B05A02. Création : 16/11/1999.