In a prospective cohort study, associations of resting heart rate with risk of coronary, cardiovascular disease, cancer, and all-cause mortality in age-specific cohorts of black and white men and women were examined over 22 years of follow-up.
Participants were employees from 84 companies and organizations in the Chicago, Illinois, area who volunteered for a screening examination.
Participants included 9,706 men aged 18-39 years, 7,760 men aged 40-59 years, 1,321 men aged 60-74 years, 6,928 women aged 18-39 years, 6,915 women aged 40-59 years, and 1,151 women aged 60-74 years at the baseline examination in 1967-1973.
Vital status was ascertained through 1992.
For fatal coronary disease, multivariate-adjusted relative risks associated with a 12 beats per minute higher heart rate (one standard deviation) were as follows :
for men aged 18-39 years, relative risk (RR)=1.27 (95% confidence interval (Cl) 1.08-1.48) ;
for men aged 40-59 years,
RR=1.13 (95% Cl 1.05-1.21) ;
for men aged 60-74 years,
RR=1.00 (95% Cl 0.89-1.12) ;
for women aged 40-59 years,
RR=1.21 (95% Cl 1.07-1.36) ;
and for women aged 60-74 years,
RR=1.16 (95% Cl 0.99-1.37).
Corresponding risks for all fatal cardiovascular diseases were similar to those for coronary death alone.
Deaths from cancer were significantly associated with heart rate in men and women aged 40-59 years.
All-cause mortality was associated with higher heart rate in men aged 18-39 years (RR=1.11,95% Cl 1.01-1. (...)
Mots-clés Pascal : Mortalité, Rythme cardiaque, Appareil circulatoire pathologie, Epidémiologie, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Mortality, Heart rate, Cardiovascular disease, Epidemiology, Risk factor, Human, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0254818
Code Inist : 002B30A01A2. Création : 16/11/1999.