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  1. Effect low frequency noise exposure on BALB/c mice splenic lymphocytes.

    Article - En anglais

    Introduction 

    Vibroacoustic disease (VAD) occurs in workers exposed for more 10 yr to large pressure amplitude and low frequency (LPALF) noise (>=90dB, <=500 Hz).

    In its initial stages (2 yr exposure), VAD is associated with an increase in infections of the respiratory tract.

    The purpose of this study is to investigate whether exposure of mice to LPALF noise leads to immunological changes as expressed by the number of different lymphocyte subpopulations in the animals'spleen.

    Methods 

    Flow cytometry analysis of spleen lymphocytes was performed in BALB/c mice that had been exposed to occupationally simulated LPALF noise (8 h. d-1,5 d. wk-1) for a total of 1272 h (approximately 8 mo).

    The following surface phenotypes of splenic lymphocytes were quantified :

    • IgM,

    • CD4,

    • CD8.

    Quantification of splenic lymphocytes from non-exposed, age-matched, control BALB/c mice was also performed.

    Results 

    Noise-exposed BALB/c mice had decreased T cells, involving both helper (CD4+) and cytotoxic (CD8+) lymphocytes, and also of IgM+B lymphocytes.

    Conclusion 

    The data indicate that relatively short term exposure (3 mo) to LPALF noise induces a decrease in spleen lymphocytes in mice which is particularly significant (p<0.003) in CD8+T lymphocytes.

    The data suggest that exposure to LPALF noise causes changes in the immune system of mice.

    This is in agreement with previous human studies where VAD patients presented an enhancement in the number of circulating CD8+lymphocytes.

    Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Nuisance acoustique, Industrie aéronautique, Exposition professionnelle, Immunomodulation, Lymphocyte, Système immunitaire, Rate, Temps exposition, Animal, Aviation pathologie, Médecine aérospatiale, Facteur milieu, Médecine travail, Souris, Rodentia, Mammalia, Vertebrata, Modèle animal

    Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Noise pollution, Aeronautic industry, Occupational exposure, Immunomodulation, Lymphocyte, Immune system, Spleen, Exposure time, Animal, Aviation medicine, Space medicine, Environmental factor, Occupational medicine, Mouse, Rodentia, Mammalia, Vertebrata, Animal model

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0254708

    Code Inist : 002B16M. Création : 16/11/1999.