A community-based survey to determine the prevalence of human T-cell lymphotropic type I (HTLV-I) and type II (HTLV-II) virus infections in mothers and children in south-western Nigeria was carried out using blood samples collected in 1993.
A multistage cluster, random sampling procedure was used to select 460 mother-child pairs (476 children because there were 16 sets of twins) from 14 enumeration areas.
A commercially available, whole HTLV-I lysate antigen-based ELISA method was used to screen for HTLV-I and HTLV-II antibodies in the samples.
A synthetic peptide antigen-based ELISA was then used to differentiate between antibody reactivity to either HTLV-I or HTLV-II.
Reactivity to HTLV-I or HTLV-II antibodies was found in 4.3 per cent (20/460) of mothers and in 1.1 per cent (5/476) of children in both rural and urban communities and all the positive children were males.
None of the 16 sets of twins in this study was positive for either HTLV-I or HTLV-II.
Also none of the mother-child paired sera tested showed concordance for either HTLV-I or HTLV-II antibody positivity.
The lack of concordance between mother and child sera suggests that vertical transmission may not be the major route of transmission of HTLV infection to children in south-western Nigeria. (...)
Mots-clés Pascal : Virus HTLV1, Retroviridae, Virus, Virus HTLV2, Prévalence, Virose, Infection, Mère, Enfant, Homme, Femelle, Epidémiologie, Transmission verticale, Nigéria, Afrique
Mots-clés Pascal anglais : HTLV-I virus, Retroviridae, Virus, HTLV-II virus, Prevalence, Viral disease, Infection, Mother, Child, Human, Female, Epidemiology, Vertical transmission, Nigeria, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0254147
Code Inist : 002B05B02D. Création : 16/11/1999.