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  1. The effect of chronic exposure to low frequency noise on rat tracheal epithelia.

    Article - En anglais


    Vibroacoustic Disease (VAD) is a multi-systemic entity caused by occupational or chronic exposure to large pressure amplitude and low frequency (LPALF) noise (>=90 dB SPL, <=500 Hz).

    The clinical picture involves extra-auditory pathology, such as neurological disturbances, respiratory disorders and cardiovascular problems.

    Among the first complaints of VAD patients are coughing, bronchitis, and inflammation or infection of the oral cavity and the upper respiratory pathways.

    The goal of ths study was to investigate the effects of occupationally simulated LPALF noise exposure on rat tracheal epithelium to determine if they could explain the symptoms found in VAD patients.


    We exposed 20 Wistar rats to occupationally simulated (8 h. d-1,5d. wk-1) LPALF noise for an accumulated total of 1236 h. The control group consisted of 10 age-matched rats, kept in equal conditions but in silence.

    Histological and ultrastructural studies were performed on the tracheal epithelia of both populations.


    The most dramatic changes were identified in the ciliated cells of the exposed rats.

    There were frequent images of shaggy or necrotic cilia as well as regularly to partially sheared cilia.

    Also, there were frequent images of different stages of cilia recovery.


    Occupationally simulated exposure to LPALF noise can cause important changes in ciliated cells rat tracheal epithelia.

    This may partially explain the clinical findings observed in VAD patients.

    Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Nuisance acoustique, Exposition professionnelle, Chronique, Trachée, Epithélium, Cellule ciliée, Animal, Modèle animal, Facteur milieu, Aviation pathologie, Médecine aérospatiale, Appareil respiratoire pathologie, Voie respiratoire, Médecine travail, Rat, Rodentia, Mammalia, Vertebrata, Traumatisme, Agent physique

    Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Noise pollution, Occupational exposure, Chronic, Trachea, Epithelium, Ciliated cell, Animal, Animal model, Environmental factor, Aviation medicine, Space medicine, Respiratory disease, Respiratory tract, Occupational medicine, Rat, Rodentia, Mammalia, Vertebrata, Trauma, Physical agent

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0253677

    Code Inist : 002B16M. Création : 16/11/1999.