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  1. Airway Flow limitation in patients with Vibroacoustic disease.

    Article - En anglais


    Vibroacoustic disease (VAD) is a pathology caused by occupational exposure to large pressure amplitude and low frequency (LPALF) noise (>=90 dB SPL, <=500 Hz), and has been the object of study by this group for the past 20 yr.

    In a group of 140 VAD-diagnosed patients, 7 non-smoker aircraft technicians developed clinical signs of respiratory insufficiency at an early age.

    Previously, multi-focal fibrosis had been observed in the lung of Wistar rats exposed to occupationally simulated LPALF noise and with no possibility of contamination by fumes, dust or other chemical agents.

    The goal of this study is to compare pulmonary imaging and/or functional changes in two age-and exposure-time matched groups of VAD-diagnosed aircraft technicians, with and without airflow limitation symptoms.


    In a population of 140 individuals occupationally exposed to LPALF noise and diagnosed with VAD, we excluded the smokers (45 cases) and selected 7 individuals with complaints of airway flow limitations, average age 42.3 yr (SD=2.3).

    From the remaining non-smokers without respiratory complaints, we selected a group of 15, age-matched patients (average age 36 yr, SD=6.5).

    All subjects received a high-resolution CT scan of the chest and respiratory function tests consisting of body plethysmography, spirometry and metacholine airway provocation. (...)

    Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Nuisance acoustique, Industrie aéronautique, Exposition professionnelle, Traumatisme, Agent physique, Insuffisance respiratoire, Pléthysmographie, Spirométrie, Fibrose, Poumon, Aviation pathologie, Médecine aérospatiale, Facteur milieu, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie, Homme

    Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Noise pollution, Aeronautic industry, Occupational exposure, Trauma, Physical agent, Respiratory failure, Plethysmography, Spirometry, Fibrosis, Lung, Aviation medicine, Space medicine, Environmental factor, Occupational medicine, Respiratory disease, Lung disease, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0253676

    Code Inist : 002B16M. Création : 16/11/1999.