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  1. Morphological changes in rat lung parenchyma exposed to low frequency noise.

    Article - En anglais

    Background 

    Airway flow limitation is has been identified in non-smoker aeronautical technicians who are exposed to long term (>=10 yr) large pressure amplitude and low frequency (LPALF) noise (>=90 dB, <=500 Hz).

    Considering this work environment, some kind of pulmonary impairment would be expected, given the probable, but not de facto, existence of fuel exhausts and vapors.

    In the course of morphofunctional studies of rat pleura exposed to LPALF noise environments, intense subpleural fibrosis was identified.

    Thus, we decided to study the deep lung parenchyma of these noise-exposed rodents.

    Methods 

    One group of five Wistar rats was exposed to LPALF noise for a cumulative 4000 h, and another of five rats were exposed for a cumulative of 5000 h. The control group consisted of 10, age-matched, Wistar rats that were kept in the same conditions, but in silence.

    Fragments of lung parenchyma were extracted after sacrifice, and processed for light microscopy, and for scanning and transmission electron microscopy.

    Results 

    Focal interstitial fibrosis of the deep lung parenchyma were identified as well as changes in the small bronchial cilia.

    The amount of brush cells was increased in the locations where microvilli were abnormal.

    An obvious increase of alveolar type II pneumocyte cells was observed with numerous, large and confluent lamellar bodies. (...)

    Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Nuisance acoustique, Industrie aéronautique, Exposition professionnelle, Morphologie, Parenchyme, Poumon, Animal, Fibrose, Modèle animal, Aviation pathologie, Médecine aérospatiale, Facteur milieu, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie, Rat, Rodentia, Mammalia, Vertebrata, Cellule alvéolaire type II

    Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Noise pollution, Aeronautic industry, Occupational exposure, Morphology, Parenchyma, Lung, Animal, Fibrosis, Animal model, Aviation medicine, Space medicine, Environmental factor, Occupational medicine, Respiratory disease, Lung disease, Rat, Rodentia, Mammalia, Vertebrata, Alveolar type II cell

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0253204

    Code Inist : 002B16M. Création : 16/11/1999.