logo BDSP

Base documentaire

  1. ERP P300 and brain magnetic resonance imaging in patients with vibroacoustic disease.

    Article - En anglais


    Subjects occupationally exposed to large pressure amplitude (>= 90 dB SPL) and low frequency (<= 500 Hz) (LPALF) noise for long term periods (>10 yr) can develop vibroacoustic disease (VAD).

    One of the earliest complaints of VAD patients deals with memory and attention disturbances.

    On the other hand, in over 50% of these patients, magnetic resonance imaging (MRI) of the CNS revealed cortical atrophy and dilation of the perivascular spaces, and small hyperintense lesions in T2 of the cerebral white matter, basal ganglia, and brainstem.

    The purpose of this study is to investigate whether there is any relationship between these morphological changes and the event-related potentials (ERP) P300 parameters.


    Sixty aeronautical workers with more than 10 yr of LPALF noise exposure were studied using brain MRI and ERP P300.

    A careful neurological examination had been previously performed on all of them.


    The neurological examination revealed abnormalities in 80%, the most common finding being the archaic palmo-mental reflex.

    Some 37 subjects had hyperintense foci in T2 of the subcortical and periventricular white matter, the basal ganglia and the brainstem.

    Comparing the ERP P300 amplitude and latency values, morphology and topography, obtained in these 37 subjects with the data from the 23 who did not have any morphological changes in CNS, we found a strong correlation between the brain MRI lesions and the neurophysiological changes (p<0. (...)

    Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Nuisance acoustique, Industrie aéronautique, Exposition professionnelle, Traumatisme, Agent physique, Trouble cognition, Potentiel évoqué, Réflexe palmomentonnier, Physiopathologie, Aviation pathologie, Médecine aérospatiale, Facteur milieu, Système nerveux central pathologie, Médecine travail, Homme, Potentiel P300

    Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Noise pollution, Aeronautic industry, Occupational exposure, Trauma, Physical agent, Cognitive disorder, Evoked potential, Palmomental reflex, Pathophysiology, Aviation medicine, Space medicine, Environmental factor, Central nervous system disease, Occupational medicine, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0253200

    Code Inist : 002B16M. Création : 16/11/1999.