Sister chromatid exchange analysis in workers exposed to noise and vibration.
There has been a growing interest in the combined effects of noise and vibration.
In a population of aeronautical workers diagnosed with vibroacoustic disease (VAD), a large incidence of malignancy was detected.
These workers were exposed to large pressure amplitude (LPA) (>= 90 dB SPL) noise, with energy content concentrated within the low frequency (LF) bands (<= 500 Hz) and whole-body vibration (WBV).
To our knowledge, there are no studies conducted in humans or animals that address the issue of the potential genotoxic effects of vibration combined with noise.
In the present study, the levels of sister chromatid exchanges (SCE) and of cells with high frequencies of SCE (HFC) were analyzed in peripheral blood lymphocytes of workers employed in various occupations within the aeronautical industry.
SCE and HFC were analyzed in lymphocytes of 50 workers occupationally exposed to noise and vibration and of 34 office-worker controls (G0).
The exposed group included : 10 hand-vibrating tool operators (G1), 15 engine test cell technicians (G2), 12 aircraft run-up technicians (G3) and 13 Portuguese Air Force helicopter pilots (G4).
Groups 2-4 were exposed to WBV and LPALF noise ; group 1 was exposed to LPA high frequency noise and local vibration. (...)
Mots-clés Pascal : Bruit, Basse fréquence, Vibration, Industrie aéronautique, Exposition professionnelle, Nuisance acoustique, Echange chromatide soeur, Lymphocyte, Traumatisme, Agent physique, Malignité, Aviation pathologie, Médecine aérospatiale, Facteur milieu, Médecine travail, Homme
Mots-clés Pascal anglais : Noise, Low frequency, Vibration, Aeronautic industry, Occupational exposure, Noise pollution, Sister chromatid exchange, Lymphocyte, Trauma, Physical agent, Malignancy, Aviation medicine, Space medicine, Environmental factor, Occupational medicine, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0253121
Code Inist : 002B16M. Création : 16/11/1999.