Environmental risk factors for respiratory and skin atopy : Results from epidemiological studies in former East and West Germany.
Symposium of the Collegium Internationale Allergologicum. Corfu, GRC, 1998/09/12.
The fall of the Berlin wall in 1989 offered the unique opportunity to compare populations of a similar genetic and geographic background which had been living under quite different environmental exposure conditions for over 40 years.
Since 1990 comparative epidemiological studies were performed between various regions in former East and West Germany with yearly questionnaires and 3 years'physical, dermatological, allergological and exposure examination in a total of about 30,000 preschool children.
There were striking differences between the various German regions with higher prevalence rates of respiratory atopy (hay fever, asthma) and atopic sensitization (prick test, RAST) in West Germany, while atopic eczema was significantly higher in East Germany (17.5 vs. 11.4% in West Germany).
Total serum IgE levels were markedly higher in children in the east of Germany, similarly to the prevalence of parasitic infestation (questionnaire data as well as positive ascaris RAST).
In multivariate logistic regression analysis the following factors were significantly associated with atopic eczema : animal contact (odds ratio, OR 2.9), animal furs in the bedroom (OR 2.2), use of gas without ventilation (OR 1.7) and living near road with heavy traffic (OR 1.7).
Furthermore, socioeconomic factors measured as parental educational status (university vs. elementary school) were significantly associated (OR 2.3) with atopy. (...)
Mots-clés Pascal : Asthme, Allergie, Rhinite, Eczéma, Pathogénie, Environnement, Pollution, Facteur risque, Allemagne(république fédérale), Allemagne, Europe, Allemagne(république démocratique), Etude comparative, Enfant, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Epidémiologie, ORL pathologie, Nez pathologie, Peau pathologie
Mots-clés Pascal anglais : Asthma, Allergy, Rhinitis, Eczema, Pathogenesis, Environment, Pollution, Risk factor, West Germany, Germany, Europe, East Germany, Comparative study, Child, Human, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Epidemiology, ENT disease, Nose disease, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0252721
Code Inist : 002B06C01. Création : 16/11/1999.