Simulations of pertussis epidemiology in the United States : effects of adult booster vaccinations.
An expanded pertussis (whooping cough) vaccination program which includes adult boosters every 10 yr is studied using computer simulations of two models.
These age-structured pertussis transmission models include waning of both infection-acquired and vaccine-induced immunity, and vaccination of children corresponding to the vaccination coverage since 1940.
Adult vaccinations cause a larger boost in the immunity level in the second model than in the first model.
In the simulations the addition of adult pertussis booster vaecinations every 10 yr is beneficial in reducing adult incidence, but causes only modest reductions in the incidence in infants and young children.
These simulations suggest that a careful cost effectiveness analysis is needed before implementation of an adult pertussis vaccination program.
Mots-clés Pascal : Etats Unis, Amérique du Nord, Amérique, Simulation, Vaccination, Coqueluche, Bactériose, Infection, Enfant, Homme, Programme sanitaire, Simulation ordinateur, Modélisation, Age, Appareil respiratoire pathologie
Mots-clés Pascal anglais : United States, North America, America, Simulation, Vaccination, Whooping cough, Bacteriosis, Infection, Child, Human, Sanitary program, Computer simulation, Modeling, Age, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0246518
Code Inist : 002B05B02E. Création : 16/11/1999.