Relation of Lake Ontario fish consumption, lifetime lactation, and parity to breast milk polychlorobiphenyl and pesticide concentration.
Health Conference'97 - Great Lakes/St. Lawrence. Montréal, PQ, CAN, 1997/05/12.
Lactating female members and spouses of male members of the New York State Angler Cohort who agreed to provide breast milk samples were the subjects of this study.
Questionnaires were provided to participants focusing on Lake Ontario fish consumption, reproductive history, and lactation history.
Milk samples were analyzed for 77 polychlorinated biphenyls (PCB) congeners, 1,1-dichloro-2,2-bis (p-chlorophenyl) - ethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), hexachlorobenzene (HCB), and 1,1a, 2,2,3,3a, 4,5,5,5a, 5b, 6-dodecachlorooctahydro-1,3,4-methano-1H-cyclobuta[cd]pentalene (Mirex).
The percentage of samples with quantifiable levels, above the limit of detection (LOD), varied among the individual congeners from 10 to 100%. Nine PCB congeners (designated by their IUPAC No.) and DDE were found in all of the 100 samples analyzed.
These include the following, in decreasing order of concentration : DDE>153>138>180>118>187>188>177>200.
Total PCB concentrations were estimated by taking the sum of the concentrations of all PCB congeners (up to 77 congeners) above their respective LOD in a given sample.
PCB concentrations increased with increasing concentration of milk lipid.
Lipid adjusted PCB concentrations increased as a function of maternal age.
PCB congener profiles in milk favored the higher chlorinated congeners, with the four highest congeners having 5 to 7 chlorine atoms. (...)
Mots-clés Pascal : Association toxique, Allaitement, Produit dégradation, Contamination, Canada, Amérique du Nord, Amérique, Produit pêche, Grands Lacs Amérique, Milieu eau douce, Santé et environnement, Facteur risque, Relation mère enfant, Nourrisson, Homme, Lait maternel, Consommation alimentaire, Epidémiologie, Parité, Corrélation, Chlore Composé organique, Femelle, DDE, Biphényle(polychloro), Lac Ontario
Mots-clés Pascal anglais : Toxic association, Breast feeding, Degradation product, Contamination, Canada, North America, America, Seafood, Great Lakes of America, Freshwater environment, Health and environment, Risk factor, Mother child relation, Infant, Human, Breast milk, Food intake, Epidemiology, Parity, Correlation, Chlorine Organic compounds, Female, DDE, Polychlorobiphenyl
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0245330
Code Inist : 002B03H. Création : 16/11/1999.