Health Conference'97 - Great Lakes/St. Lawrence. Montréal, PQ, CAN, 1997/05/12.
Exposure to contaminants in Great Lakes fish has been linked to impaired neuropsychological functioning in children, but neurological function of exposed adults has not been evaluated.
This report describes a cross-sectional analysis of the effects of PCB/DDE exposure from contaminated fish on fine motor function in older adults.
The subjects were 50-90-year-old Michigan residents who were members of a previously established study cohort.
Fisheaters ate 24 lbs or more of sport-caught Lake Michigan fish/year at the time they were originally recruited in 1980-1982.
Age-and sex-matched non-fisheaters ate 6 or fewer lbs/year.
Outcome measures were scores on the Static Motor Steadiness Test (SMST) and Grooved Pegboard Test (GPT).
PCB/DDE exposure was determined through serum analyses performed at the time of recruitment into the present study in 1993-1995.
Because of the high correlation between serum PCB and DDE levels in this sample (Spearman r=0.64, P<0.0001), the effects of the two contaminants were assessed jointly using a single derived exposure variable : Low=both PCB and DDE at or below the medians of their respective distributions, intermediate=PCB and/or DDE in the third quartile, and high=PCB and/or DDE in the upper quartile.
In unadjusted analyses, high exposure to PCBs/DDE was associated with significantly poorer performance on the GPT (P=0.03). (...)
Mots-clés Pascal : Biphényle(polychloro), Etude comparative, Corrélation, DDE, Taux, Sang, Toxicité, Liquide biologique, Sénescence, Trouble neurologique, Trouble motricité, Personne âgée, Homme, Sexe, Age, Etude transversale, Poisson comestible, Aliment, Consommation alimentaire, Habitude alimentaire, Pollution eau, Milieu eau douce, Produit pêche, Système nerveux pathologie
Mots-clés Pascal anglais : Polychlorobiphenyl, Comparative study, Correlation, DDE, Rate, Blood, Toxicity, Biological fluid, Senescence, Neurological disorder, Motility disorder, Elderly, Human, Sex, Age, Cross sectional study, Edible fish, Food, Food intake, Food habit, Water pollution, Freshwater environment, Seafood, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0245319
Code Inist : 002B03H. Création : 16/11/1999.