A systematic overview of the use of diary cards, quality-of-life questionnaires, and psychometric tests in treatment trials of Helicobacter pylori-positive and - negative non-ulcer dyspepsia.
Our aim was to evaluate the use of diary cards, quality-of-life questionnaires, and psychometric tests in treatment trials of non-ulcer dyspepsia.
Data sources were a Medline search (up to 1966) and a manual search of five gastrointestinal journals (up to 1980) for original, randomized, double-blind, placebo-controlled trials with at least 20 patients which evaluated treatment regimens for non-ulcer dyspepsia.
Of the 67 eligible studies, 31 used diary cards.
Diary cards were used alone in 15 of the 31 studies (48%), whereas the others (52%) also used a physician assessment.
The symptoms assessed by diary cards were epigastric pain (100%), nausea/vomiting (65%), heartburn (52%), belching (39%), regurgitation (29%), fullness (29%), and bloating (23%). Forty-five per cent also recorded antacid use.
Severity of outcome measures was assessed by a visual analogue scale in 5 of the 31 studies (16%), Likert scales in 17 studies (55%), and unclear methods in 3 studies (10%). For statistical analysis daily averages of symptoms were used in 5 of the 31 studies (16%), weekly averages in 11 studies (35%), and 2-week intervals during the treatment period in the rest, with some studies using a combination (such as daily and weekly averages).
Only 3 of the 31 studies (8%) checked for compliance with diary card data.
None of the studies mention anything about missing data and how this was handled. (...)
Mots-clés Pascal : Dyspepsie, Fonctionnelle, Association morbide, Gastrite, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Evaluation, Symptomatologie, Questionnaire, Qualité vie, Psychométrie, Efficacité traitement, Métaanalyse, Homme, Appareil digestif pathologie, Estomac pathologie
Mots-clés Pascal anglais : Dyspepsia, Functional, Concomitant disease, Gastritis, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Evaluation, Symptomatology, Questionnaire, Quality of life, Psychometrics, Treatment efficiency, Metaanalysis, Human, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0245265
Code Inist : 002B13B03. Création : 16/11/1999.