Although diet and its constituents have been studied extensively as risk factors for colon cancer, much less is known about how specific types of fluid influence colon cancer risk.
In this study, we explored associations between colon cancer and total fluids, water and methylxanthine-containing beverages such as coffee, tea and cola ; data were obtained from 1,993 incident cases of colon cancer and 2,410 population-based controls living in California, Utah and Minnesota.
Our primary objective was to determine the influence on associations of amount consumed, confounding and effect modification.
We observed few important differences between colon cancer and fluid consumption for all subjects combined.
Among men, low levels of coffee intake were associated with an increased risk of colon cancer relative to non-consumers of coffee (OR 1.32,95% CI 1.02-1.67), while at high levels of consumption, an inverse association was observed (OR 0.81,95% Cl 0.58-1.12).
The observed associations were only slightly influenced by consumption of water or other potential confounding factors, but changing the referent group to those consuming one cup of coffee per day or less resulted in a stronger association and a more significant inverse linear trend (OR 0.71,95% CI 0.53-0.96).
The associations with coffee and caffeine-and methylxanthine-containing beverages were strongest for proximal tumors in men.
High levels of water intake, however, were protective for distal tumors (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Facteur risque, Epidémiologie, Boisson, Xanthine dérivé, Café, Thé, Cola, Sterculiaceae, Dicotyledones, Angiospermae, Spermatophyta, Eau, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Risk factor, Epidemiology, Beverage, Xanthine derivatives, Coffee, Tea, Cola, Sterculiaceae, Dicotyledones, Angiospermae, Spermatophyta, Water, United States, North America, America, Human, Digestive diseases, Intestinal disease, Colonic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0244974
Code Inist : 002B13B01. Création : 16/11/1999.