Determinants of peak bone mass : Clinical and genetic analyses in a young female canadian cohort.
Peak bone mass has been shown to be a significant predictor of risk for osteoporosis.
Previous studies have demonstrated that skeletal mass accumulation is under strong genetic control, and efforts have been made to identify candidate loci.
Determinants of peak bone mass also include diet, physical activity, hormonal status, and other clinical factors.
The overall contribution of these factors, genetic and nongenetic, and their interaction in determining peak bone density status have not been delineated.
Six hundred and seventy-seven healthy unrelated Caucasian women ages 18-35 years were assessed.
A detailed, standardized interview was conducted to evaluate lifestyle factors, menstrual and reproductive history, medical conditions, medication use, and family history of osteoporosis.
Bone mineral density (BMD) was measured at the lumbar spine (L2-L4) and the femoral neck (hip) using dual-energy X-ray absorptiometry.
Genotyping of the vitamin D receptor (VDR) locus at three polymorphic sites (BsmI, ApaI, and TaqI) was performed.
In bivariate analyses, BMD at the lumbar spine and hip was positively correlated with weight, height, body mass index (BMI), and level of physical activity, both now and during adolescence, but negatively correlated with a family history of osteoporosis.
Hip, but not spine BMD, correlated positively with dietary intake of calcium, and negatively with amenorrhea of more than 3 months, with caffeine intake, and with age. (...)
Mots-clés Pascal : Masse osseuse, Densité, Elément minéral, Facteur milieu, Déterminisme génétique, Facteur prédictif, Epidémiologie, Caucasoïde, Canada, Amérique du Nord, Amérique, Os, Système ostéoarticulaire, Adulte jeune, Homme, Femelle
Mots-clés Pascal anglais : Bone mass, Density, Inorganic element, Environmental factor, Genetic determinism, Predictive factor, Epidemiology, Caucasoid, Canada, North America, America, Bone, Osteoarticular system, Young adult, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0244963
Code Inist : 002A23A. Création : 16/11/1999.