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  1. Urinary cotinine and exposure to parental smoking in a population of children with asthma.

    Article - En anglais

    Background 

    Studies of the effects of tobacco smoke often rely on reported exposure to cigarette smoke, a measure that is subject to bias.

    We describe here the relationship between parental smoking exposure as assessed by urinary cotinine excretion and lung function in children with asthma.

    Methods 

    We studied 90 children 4-14 years of age, who reported a confirmed diagnosis or symptoms of asthma.

    In each child, we assessed baseline pulmonary function (spirometry) and bronchial responsiveness to carbachol stimulation.

    Urinary cotinine was measured by HPLC with ultraviolet detection.

    Results 

    Urinary cotinine concentrations in the children were significantly correlated (P<0.001) with the number of cigarettes the parents, especially the mothers, smoked.

    Bronchial responsiveness to carbachol (but not spirometry test results) was correlated (P<0.03) with urinary cotinine in the children.

    Conclusion 

    Passive smoke exposure increases the bronchial responsiveness to carbachol in asthmatic children.

    Mots-clés Pascal : Enfant, Homme, Tabagisme passif, Cotinine, Marqueur biologique, Urine, Etiopathogénie, Epidémiologie, France, Europe, Asthme, Liquide biologique, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie

    Mots-clés Pascal anglais : Child, Human, Passive smoking, Cotinine, Biological marker, Urine, Etiopathogenesis, Epidemiology, France, Europe, Asthma, Biological fluid, Respiratory disease, Obstructive pulmonary disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0244498

    Code Inist : 002B06C02. Création : 16/11/1999.