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  1. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males.

    Article - En anglais

    Several recent studies evaluated a possible effect of the prothrombotic polymorphisms such as 5,10 methylenetetrahydrofolate reductase (MTHFR) nt 677C-T, factor V (F V) nt 1691G - A (F V Leiden), and factor II (F II) nt 20210 G - A on the risk of myocardial infarction.

    In the present study, we analyzed the effect of these prothrombotic polymorphisms, as well as apolipoprotein (Apo) E4, smoking, hypertension, diabetes mellitus, and hypercholesterolemia, on the risk of myocardial infarction in young males.

    We conducted a case-control study of 112 young males with first acute myocardial infarction (AMI) before the age of 52 and 187 healthy controls of similar age.

    The prevalences of heterozygotes for F V G1691A and F II G20210A were not significantly different between cases and controls (6.3% V 6.4% and 5.9% v 3.4% among cases and controls, respectively).

    In contrast, the prevalence of MTHFR 677T homozygosity and the allele frequency of Apo E4 were significantly higher among patients (24.1% v 10.7% and 9.4% V 5.3% among cases and controls, respectively).

    Concomitant presence of hypertension, hypercholesterolemia, or diabetes and one or more of the four examined polymorphisms increased the risk by almost ninefold (odds ratio [OR]=8.66 ; 95% confidence interval [Cl], 3.49 to 21.5) and concomitant smoking by almost 18-fold (OR=17.6 ; 95% Cl, 6.30 to 48.9). (...)

    Mots-clés Pascal : Infarctus, Myocarde, Facteur risque, Hypertension artérielle, Epidémiologie, Etude cas témoin, Diabète, Israël, Asie, Hypercholestérolémie, Tabagisme, Apolipoprotéine E, Prothrombine, Facteur coagulation, Variabilité génétique, Polymorphisme, Gène, Adulte jeune, Homme, Lipide, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Génétique, Endocrinopathie, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie

    Mots-clés Pascal anglais : Infarct, Myocardium, Risk factor, Hypertension, Epidemiology, Case control study, Diabetes mellitus, Israel, Asia, Hypercholesterolemia, Tobacco smoking, Apolipoprotein E, Prothrombin, Coagulation factor, Genetic variability, Polymorphism, Gene, Young adult, Human, Lipids, Cardiovascular disease, Coronary heart disease, Myocardial disease, Genetics, Endocrinopathy, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0244494

    Code Inist : 002B12A03. Création : 16/11/1999.