Acute isoniazid exposures and antidote availability.
Over the past 10 years the reported incidence of acute isoniazid (INH) - related poisonings has increased, with 507 cases reported in 1996.
Parenteral pyridoxine is the antidote for INH-induced seizures, but 5-g aliquot recommended to treat an ingestion of unknown quantity of INH is not always readily available to emergency physicians.
To determine the hospital availability of pyridoxine.
One hundred thirty questionnaires were distributed nationwide to the pharmacies and emergency departments (ED) of hospitals containing pediatric emergency medicine (PEM) fellowships and/or emergency medicine (EM) residencies Questions were posed regarding the availability, quantity, location, and deemed importance of pyridoxine at each institution.
Responses were received from 81% of the hospitals with fellowships and 80% of the hospitals with residencies.
Half of the former and one third of the latter reported not having the recommended 5-g aliquot available.
Eighty percent of the hospitals with PEM programs and 71% with EM residencies with an adequate stock store it in the hospital's pharmacy, as opposed to in the ED.
Thirty-four states were represented, 18 of which have experienced an increase in tuberculosis (TB) from 1993 to 1994 ; 6/18 (33%) of those did not have the pyridoxine available, and 7/18 (39%) did not deem it necessary. (...)
Mots-clés Pascal : Isoniazide, Antituberculeux, Chimiothérapie, Pyridoxine, Intoxication, Antidote, Tuberculose, Mycobactériose, Bactériose, Infection, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Traitement, Aigu, Disponibilité, Hôpital, Système nerveux pathologie, Enfant, Homme
Mots-clés Pascal anglais : Isoniazid, Antituberculous agent, Chemotherapy, Pyridoxine, Poisoning, Antidote, Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Treatment, Acute, Availability, Hospital, Nervous system diseases, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0241595
Code Inist : 002B02V. Création : 16/11/1999.