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  1. Activated protein C Resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism.

    Article - En anglais

    Background 

    Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism.

    Objective 

    To evaluate the risk for venous thromboembolism associated with the factor V Leiden mutation or with resistance to activated protein C in the general population.

    Design 

    Cross-sectional survey.

    Setting 

    General community of Vicenza, Italy.

    Patients 

    A population-based sample of 15 109 white persons 18 to 65 years of age who were randomly selected from the census list.

    Measurements 

    Sequential validated approach based on participants'reports and Doppler ultrasonography.

    Resistance to activated protein C was investigated in all participants ; 2134 participants with resistance to activated protein C were screened for the factor V Leiden mutation.

    Results 

    Carriers of the factor V Leiden mutation had a relative risk of 3.3 (95% Cl, 1.7 to 6.1) for venous thromboembolism before 65 years of age.

    The fraction of cases attributable to the factor V Leiden mutation was 6.6%. By 65 years of age, 5.7% of carriers of the mutation had had venous thromboembolism, mostly after surgery.

    Participants with a reduced response to activated protein C were at higher risk even if they did not carry the mutation (odds ratio, 1.7 [Cl, 1.0 to 2.7]) ; the attributable risk for venous thromboembolism was 5.1%. (...)

    Mots-clés Pascal : Thromboembolie, Veine, Prévalence, Facteur V Leiden, Mutation, Résistance chimique, Protéine C réactive, Etude transversale, Caucasoïde, Facteur risque, Homme, Italie, Europe, Evaluation, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Biologie moléculaire

    Mots-clés Pascal anglais : Thromboembolism, Vein, Prevalence, Factor V Leiden, Mutation, Chemical resistance, C reactive protein, Cross sectional study, Caucasoid, Risk factor, Human, Italy, Europe, Evaluation, Cardiovascular disease, Vascular disease, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0235834

    Code Inist : 002B12B03. Création : 16/11/1999.