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  1. Abnormalities of kidney function as a cause and a consequence of cardiovascular disease.

    Article, Communication - En anglais

    Jackson Heart Study Symposium on Cardiovascular Disease in African Americans. Jackson, MS, USA, 1997/11.

    Hypertension, left ventricular hypertrophy (LVH), hypercreatininemia, and microalbuminuria (MA) are independent risk factors for cardiovascular disease (CVD).

    Hypertension increases the risk of CVD by two-to three-fold and LVH (especially concentric) is a risk factor for coronary heart disease, heart failure, stroke, and peripheral arterial disease.

    In people with hypertension, a serum creatinine level of 1.7 mg/dL or more may be an even stronger CVD risk factor than diabetes, smoking, LVH, or systolic blood pressure.

    Similarly, MA is a strong and independent predictor of CVD morbidity and mortality in people with and without diabetes and/or hypertension.

    Impaired renal sodium handling and sodium retention are physiological hallmarks of the very early stages of heart failure.

    Heart failure is a physiologically delicate condition that can decompensate with excess dietary salt intake or over diuresis, or compensate with cautious therapy designed to block the sodium retention and simultaneously interrupt excessively activated neurohumoral mechanisms.

    Mots-clés Pascal : Appareil circulatoire pathologie, Epidémiologie, Hypertrophie, Ventricule gauche, Hypertension artérielle, Microalbuminurie, Créatininémie, Insuffisance rénale, Etude comparative, Facteur risque, Complication, Etats Unis, Amérique du Nord, Amérique, Adulte, Homme, Personne âgée, Albumine, Cardiopathie, Appareil urinaire pathologie, Protéinurie, Rein pathologie

    Mots-clés Pascal anglais : Cardiovascular disease, Epidemiology, Hypertrophy, Left ventricle, Hypertension, Microalbuminuria, Creatininemia, Renal failure, Comparative study, Risk factor, Complication, United States, North America, America, Adult, Human, Elderly, Albumin, Heart disease, Urinary system disease, Proteinuria, Kidney disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0235681

    Code Inist : 002B30A01A2. Création : 16/11/1999.