To evaluate the effects of randomly assigning smokers who have early chronic obstructive pulmonary disease (COPD) to a smoking-cessation intervention on the symptoms of chronic cough, chronic phlegm production, wheezing and shortness of breath, and to determine the effects of quitting smoking on these symptoms.
A total of 5,887 male and female smokers 35 to 60 years of age with early COPD [defined as a forced expiratory volume in the first second (FEV1) of 55% to 90% of predicted and FEV1/forced vital capacity (FVC)<0.70] were enrolled in a 5-year clinical trial.
Two-thirds of participants were randomly assigned to smoking-intervention groups and one-third to a usual-care group.
The intervention groups attended 12 intensive smoking-cessation sessions that included behavior modification techniques and the use of nicotine chewing gum.
One intervention group was treated with ipratropium bromide by inhaler ; the other intervention group received placebo inhalers.
The usual-care group was advised to stop smoking.
Smoking status was biochemically validated by salivary cotinine measurements or exhaled carbon monoxide values.
Validated 5-year sustained smoking cessation occurred in 22% of participants in the intervention compared with only 5% of participants in the usual-care group. (...)
Mots-clés Pascal : Tabagisme, Sevrage, Randomisation, Bronchopneumopathie obstructive, Précoce, Assignation, Qualité vie, Régime alimentaire, Etude longitudinale, Symptomatologie, Evaluation, Homme, Etats Unis, Amérique du Nord, Amérique, Toxicologie, Psychopathologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Tobacco smoking, Weaning, Randomization, Obstructive pulmonary disease, Early, Assignment, Quality of life, Diet, Follow up study, Symptomatology, Evaluation, Human, United States, North America, America, Toxicology, Psychopathology, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0235395
Code Inist : 002B18C05C. Création : 16/11/1999.