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  1. Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease : The Lung Health Study.

    Article - En anglais


    To evaluate the effects of randomly assigning smokers who have early chronic obstructive pulmonary disease (COPD) to a smoking-cessation intervention on the symptoms of chronic cough, chronic phlegm production, wheezing and shortness of breath, and to determine the effects of quitting smoking on these symptoms.


    A total of 5,887 male and female smokers 35 to 60 years of age with early COPD [defined as a forced expiratory volume in the first second (FEV1) of 55% to 90% of predicted and FEV1/forced vital capacity (FVC)<0.70] were enrolled in a 5-year clinical trial.

    Two-thirds of participants were randomly assigned to smoking-intervention groups and one-third to a usual-care group.

    The intervention groups attended 12 intensive smoking-cessation sessions that included behavior modification techniques and the use of nicotine chewing gum.

    One intervention group was treated with ipratropium bromide by inhaler ; the other intervention group received placebo inhalers.

    The usual-care group was advised to stop smoking.

    All participants were followed annually

    Smoking status was biochemically validated by salivary cotinine measurements or exhaled carbon monoxide values.


    Validated 5-year sustained smoking cessation occurred in 22% of participants in the intervention compared with only 5% of participants in the usual-care group. (...)

    Mots-clés Pascal : Tabagisme, Sevrage, Randomisation, Bronchopneumopathie obstructive, Précoce, Assignation, Qualité vie, Régime alimentaire, Etude longitudinale, Symptomatologie, Evaluation, Homme, Etats Unis, Amérique du Nord, Amérique, Toxicologie, Psychopathologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie

    Mots-clés Pascal anglais : Tobacco smoking, Weaning, Randomization, Obstructive pulmonary disease, Early, Assignment, Quality of life, Diet, Follow up study, Symptomatology, Evaluation, Human, United States, North America, America, Toxicology, Psychopathology, Respiratory disease, Lung disease, Bronchus disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0235395

    Code Inist : 002B18C05C. Création : 16/11/1999.