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  1. Outbreak of type A Botulism and development of a Botulism surveillance and antitoxin release system in Argentina.

    Article - En anglais

    Context Botulism is an important public health problem in Argentina, but obtaining antitoxin rapidly has been difficult because global supplies are limited.

    In January 1998, a botulism outbreak occurred in Buenos Aires.

    Objectives To determine the source of the outbreak, improve botulism surveillance, and establish an antitoxin supply and release system in Argentina.

    Design, Setting, and Participants Cohort study in January 1998 of 21 drivers of a specific bus route in urban Buenos Aires.

    Main Outcome Measure Occurrence of botulism and implication of a particular food as the vehicle causing this outbreak.

    Results Nine (43%) of 21 bus drivers developed botulism, presenting with gastroenteritis, symptoms of acute cranial nerve dysfunction including ptosis, dysphagia, blurred vision, and motor weakness.

    One driver experienced respiratory failure.

    Type A toxin was detected from 3 of 9 patients'serum samples.

    All drivers received botulism antitoxin ; there were no fatalities.

    Consumption of matambre (Argentine meat roll) was significantly associated with illness.

    Among 11 persons who ate matambre, 9 developed illness, compared with none of those who did not eat it (P<. 001).

    The matambre had been cooked in water at 78°C to 80°C for 4 hours, sealed in heat-shrinked plastic wrap, and stored in refrigerators that did not cool adequately.

    Subsequently, a botulism surveillance and antitoxin release system was established. (...)

    Mots-clés Pascal : Botulisme, Bactériose, Infection, Etude cohorte, Impact environnement, Clostridium botulinum, Clostridiaceae, Clostridiales, Bactérie, Dépistage, Surveillance, Pullulation, Prévention, Homme, Argentine, Amérique du Sud, Amérique, Appareil digestif pathologie, Toxicologie, Système nerveux pathologie, Organisation santé, Système Libération Antitoxine

    Mots-clés Pascal anglais : Botulism, Bacteriosis, Infection, Cohort study, Environment impact, Clostridium botulinum, Clostridiaceae, Clostridiales, Bacteria, Medical screening, Surveillance, Outbreak, Prevention, Human, Argentina, South America, America, Digestive diseases, Toxicology, Nervous system diseases, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0235247

    Code Inist : 002B05B02I. Création : 16/11/1999.