Objectives To investigate the effect of Chlamydia pneumoniae infection on future development of ischaemic heart disease and mortality.
Setting Caerphilly, South Wales.
Subjects Plasma specimens were collected during 1979-83 from 1773 men aged 45-59 years.
These were tested for IgG and IgA antibodies to C pneumoniae (TW183) by microimmunofluorescence.
Outcome measures 13 year mortality and incident ischaemic heart disease events were ascertained from death certificates, hospital records, and electrocardiographic changes at follow up every 4 to 5 years.
Results 642 men (36.2%) had IgG antibodies at a titre of >= 1 in 16, of whom 362 (20.4% of all men) also had detectable IgA antibodies.
The prevalence of ischaemic heart disease (a history of past or current disease) at entry was similar at all IgG antibody titres but was positively related to IgA antibody titre.
IgA antibody titre was positively correlated with plasma viscosity but not with other cardiovascular risk factors.
Incidence of ischaemic heart disease was not associated with either IgG antibody titre or IgA antibody titre, but there were stronger and significant relations of IgA antibodies with all cause mortality and fatal ischaemic heart disease, which persisted after adjustment for conventional cardiovascular risk factors.
The odds ratios associated with detectable IgA antibodies were 1.07 (95% confidence interval 0.75 to 1. (...)
Mots-clés Pascal : Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bactérie, Exploration immunologique, Plasma sanguin, Sérologie, Etude comparative, Infarctus, Myocarde, Incidence, Mortalité, IgA, IgG, Royaume Uni, Europe, Adulte, Homme, Mâle, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bacteria, Immunological investigation, Blood plasma, Serology, Comparative study, Infarct, Myocardium, Incidence, Mortality, IgA, IgG, United Kingdom, Europe, Adult, Human, Male, Cardiovascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0235066
Code Inist : 002B30A01A2. Création : 16/11/1999.