The temporal development of autoantibodies was studied in 1,353 offspring of parents with type 1 diabetes.
Islet cell antibodies (ICAs) and autoantibodies to insulin (IAAs), glutamic acid decarboxylase, and IA-2 were measured at birth, 9 months, 2 years, and 5 years of age.
At birth, no offspring had islet autoimmunity other than maternally acquired antibodies, which were shown to influence antibody prevalence up to age 6 months.
Antibodies detected thereafter were likely to represent a true de novo production, since prevalences were the same for offspring from mothers and fathers with diabetes, antibodies detected at 9 months were almost always confirmed in the 2-year sample and were associated with an increased likelihood of having or developing other antibodies.
By 2 years of age, autoantibodies appeared in 11% of offspring, 3.5% having more than one autoantibody.
IAAs were detected most frequently, and few had autoantibodies in the absence of IAAs.
In 23 offspring with multiple islet autoantibodies, IAAs preceded other antibodies in 10 cases and were first detected concurrently with other antibodies in 12 and after detection of other antibodies in 1. Development of additional antibodies and changes in levels, including decline of IAAs at older age, was frequent.
Nine children, all with IAAs and ICAs, developed diabetes.
Overall cumulative risk for disease by 5 years of age was 1.8% (95% CI 0.2-3. (...)
Mots-clés Pascal : Autoanticorps, Autoimmunité, Ilot Langerhans, Facteur risque, Etude familiale, Epidémiologie, Diabète insulinodépendant, Pancréas endocrine, Endocrinopathie, Immunopathologie, Maladie autoimmune, Enfant, Homme, Prévalence, Allemagne, Europe
Mots-clés Pascal anglais : Autoantibody, Autoimmunity, Langerhans islet, Risk factor, Family study, Epidemiology, Insulin dependent diabetes, Endocrine pancreas, Endocrinopathy, Immunopathology, Autoimmune disease, Child, Human, Prevalence, Germany, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0234331
Code Inist : 002B21E01A. Création : 16/11/1999.