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  1. The role of leptin in human obesity and disease : A review of current evidence.

    Article - En anglais

    Purpose 

    To review recent advances in the pathophysiology and potential clinical applications of leptin, an adipose tissue-derived hormone.

    Data Sources 

    A MEDLINE search of the literature on leptin and the bibliographies of relevant papers.

    Study Selection 

    All 1320 publications on leptin.

    Data Extraction 

    All identified articles were reviewed.

    Cited publications were selected on the basis of study quality and relevance to human obesity and disease.

    Data Synthesis 

    Leptin is a 16-kilodalton adipocytederived hormone that circulates in the serum in the free and bound form.

    Serum levels of leptin reflect the amount of energy stored in adipose tissue.

    Short-term energy imbalance as well as serum levels of several cytokines and hormones influence circulating leptin levels.

    Leptin acts by binding to specific receptors in the hypothalamus to alter the expression of several neuropeptides that regulate neuroendocrine function and energy intake and expenditure.

    Thus, leptin plays an important role in the pathogenesis of obesity and eating disorders and is thought to mediate the neuroendocrine response to food deprivation.

    Phase I and II trials recently showed that leptin administration to humans is safe, and ongoing phase III trials are assessing the efficacy of leptin as a treatment for obesity and related disorders. (...)

    Mots-clés Pascal : Obésité, Physiopathologie, Prévalence, Leptine, Régulation, Poids corporel, Homéostasie, Prévention, Traitement, Article synthèse, Revue bibliographique, Homme, Etats Unis, Amérique du Nord, Amérique, Etat nutritionnel, Trouble nutrition, Biologie moléculaire, Endocrinologie, Biologie cellulaire

    Mots-clés Pascal anglais : Obesity, Pathophysiology, Prevalence, Leptin, Regulation(control), Body weight, Homeostasis, Prevention, Treatment, Review, Bibliographic review, Human, United States, North America, America, Nutritional status, Nutrition disorder, Molecular biology, Endocrinology, Cell biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0234209

    Code Inist : 002B24O13. Création : 16/11/1999.