The role of leptin in human obesity and disease : A review of current evidence.
To review recent advances in the pathophysiology and potential clinical applications of leptin, an adipose tissue-derived hormone.
A MEDLINE search of the literature on leptin and the bibliographies of relevant papers.
All 1320 publications on leptin.
All identified articles were reviewed.
Cited publications were selected on the basis of study quality and relevance to human obesity and disease.
Leptin is a 16-kilodalton adipocytederived hormone that circulates in the serum in the free and bound form.
Serum levels of leptin reflect the amount of energy stored in adipose tissue.
Short-term energy imbalance as well as serum levels of several cytokines and hormones influence circulating leptin levels.
Leptin acts by binding to specific receptors in the hypothalamus to alter the expression of several neuropeptides that regulate neuroendocrine function and energy intake and expenditure.
Thus, leptin plays an important role in the pathogenesis of obesity and eating disorders and is thought to mediate the neuroendocrine response to food deprivation.
Phase I and II trials recently showed that leptin administration to humans is safe, and ongoing phase III trials are assessing the efficacy of leptin as a treatment for obesity and related disorders. (...)
Mots-clés Pascal : Obésité, Physiopathologie, Prévalence, Leptine, Régulation, Poids corporel, Homéostasie, Prévention, Traitement, Article synthèse, Revue bibliographique, Homme, Etats Unis, Amérique du Nord, Amérique, Etat nutritionnel, Trouble nutrition, Biologie moléculaire, Endocrinologie, Biologie cellulaire
Mots-clés Pascal anglais : Obesity, Pathophysiology, Prevalence, Leptin, Regulation(control), Body weight, Homeostasis, Prevention, Treatment, Review, Bibliographic review, Human, United States, North America, America, Nutritional status, Nutrition disorder, Molecular biology, Endocrinology, Cell biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0234209
Code Inist : 002B24O13. Création : 16/11/1999.