Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.
Background & Aims
Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group.
The 11307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews.
We assessed the 11307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.
DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the 11307K variant by the allele-specific oligonucleotide (ASO) method.
In persons at average risk for colorectal cancer, 11307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P=0.08).
It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P=0.02) and was not detected in 51 non-European Jews at increased cancer risk.
Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi 11307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Caractère génétique, Prévalence, Facteur risque, Hybridation, Etude familiale, Juif, Israël, Asie, Etude comparative, Ethnie, Europe, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Déterminisme génétique, Biologie cellulaire, 1307K APC Gene
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Genetic character, Prevalence, Risk factor, Hybridization, Family study, Jew, Israel, Asia, Comparative study, Ethnic group, Europe, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Genetic determinism, Cell biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0234208
Code Inist : 002B24O06. Création : 16/11/1999.