Background-To assess the frequency of chronic upper airways symptoms and to relate the presence of these symptoms to accidental exposure to chlorine and changes in lower airways symptoms, airway function, and bronchial responsiveness in a cohort of workers at risk of sporadic occupational exposure to high concentrations of chlorine Methods-Data were collected on symptom assessment, spirometry, and methacholine challenge tests from 211 workers seen twice at a 2 year interval (1992-4).
-The proportion of workers reporting chronic rhinitis was 46.9% in 1992 and 42.2% in 1994.
Chronic rhinitis reported in 1994 was significantly associated with acute exposure to chlorine (self reports, p=0.02 ; first aid reports, p=0.001).
In a multivariate logistic regression analysis the presence of reported accidents at the first aid unit (one accident, odds ratio (OR) 3.1,95% confidence interval (95% CI) 1.3 to 7.5 ; two or more accidents, OR 6.2,1.1 to 35.8) and of personal atopy (OR 5.5,2.2 to 10.8) were significant predictors of chronic rhinitis in 1994.
Chronic lower airways symptoms were more frequent in 1994 among workers reporting chronic rhinitis on both assessments than in others (p=0.03) and changes in bronchial responsiveness were more pronounced in those with persistent rhinitis (p=0.09). (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Chlore, Industrie, Homme, Rhinite, Composé irritant, Etude cohorte, Evaluation, Toxicité, Fonction respiratoire, Facteur risque, ORL pathologie, Nez pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Chlorine, Industry, Human, Rhinitis, Irritant compound, Cohort study, Evaluation, Toxicity, Lung function, Risk factor, ENT disease, Nose disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0233672
Code Inist : 002B03L02. Création : 16/11/1999.