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  1. Familial occurrence of abdominal aortic aneurysm.

    Article - En anglais

    Background 

    A family history of abdominal aortic aneurysm has been reported to increase the risk for developing the disease.

    Objective 

    To determine the risk for abdominal aortic aneurysm in first-degree relatives of patients with the disease.

    Design 

    Cross-sectional ultrasonographic screening study.

    Setting 

    University Central Hospital, Helsinki, Finland.

    Patients 

    238 of 325 living first-degree relatives of patients having surgery for abdominal aortic aneurysm (age>50 years ; 98 men and 110 women) and 281 controls (135 men and 149 women) without a family history of abdominal aortic aneurysm.

    Measurements 

    Ultrasonography was used to measure aortic diameter in 101 male relatives and 140 female relatives (241 of the 325 persons at risk [74% ]) and in 281 controls.

    Results 

    Three siblings had already undergone surgery for abdominal aortic aneurysm.

    Eleven siblings (all brothers) (11 of 101 [10.9% ]) had ultrasonographic evidence of abdominal aortic aneurysm (aortic diameter>30 mm).

    In the control group, 2 men (1.5%) and 2 women (1.3%) had an aneurysm.

    Thirty siblings and no controls had dilatation of the abdominal aorta (aortic diameter, 20 to 29 mm).

    Neither the age nor the sex of the proband affected risk for developing abdominal aortic aneurysm among first-degree relatives.

    Family history increased the risk for an aneurysm by 4.33-fold (95% Cl, 1.32-fold to 14.23-fold), male sex increased the risk by 12.21-fold (Cl, 2.63-fold to 56. (...)

    Mots-clés Pascal : Anévrysme, Aorte abdominale, Facteur risque, Fratrie, Etude transversale, Prévalence, Imagerie ultrasonore, Homme, Finlande, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Milieu familial, Héréditaire, Radiodiagnostic, Imagerie médicale

    Mots-clés Pascal anglais : Aneurysm, Abdominal aorta, Risk factor, Sibling, Cross sectional study, Prevalence, Ultrasound imaging, Human, Finland, Europe, Cardiovascular disease, Vascular disease, Family environment, Hereditary, Radiodiagnosis, Medical imagery

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0233637

    Code Inist : 002B24C05. Création : 16/11/1999.