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  1. Fulltext. The effects on fetal development of high alpha-fetoprotein and maternal smoking.

    Article - En anglais



    This study determined the risk of impaired fetal growth resulting from the interaction between maternal smoking during pregnancy and unexplained elevated concentrations of maternal serum alpha-fetoprotein (MSAFP).


    This observational study involved 123 pregnant smokers with unexplained second-trimester elevated concentrations of MSAFP, 827 smokers with normal levels, and 471 nonsmokers with raised levels.


    By logistic regression coincident smoking and elevated MSAFP levels were found to be associated with increases in the low basic risks of prematurity, small-for-gestational-age births, low birthweight, and need for neonatal care.


    Maternal smoking has ana adverse effect on fetal development in pregnancies with unexplained elevated MSAFP concentrations.

    Such pregnancies merit close surveillance.

    Mots-clés Pascal : Tabagisme, Mère, Développement foetal, Poids naissance faible, Foetoprotéine alpha, Concentration, Plasma sanguin, Deuxième trimestre, Epidémiologie, Facteur risque, Foetus, Finlande, Europe, Gestation, Gestation pathologie, Prématurité, Nouveau né pathologie

    Mots-clés Pascal anglais : Tobacco smoking, Mother, Fetal development, Low birth weight, alpha-Fetoprotein, Concentration, Blood plasma, Second trimester, Epidemiology, Risk factor, Fetus, Finland, Europe, Pregnancy, Pregnancy disorders, Prematurity, Newborn diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0229334

    Code Inist : 002B20F02. Création : 16/11/1999.