The authors investigated the possible association between a mother's nausea during pregnancy and her child's risk for a congenital heart defect using data from the population-based Atlanta Birth Defects Case-Control Study conducted in 1982-1983.
Case infants (n=998) had nonsyndromic congenital heart defects and control infants (n=3,029) had no congenital defects.
Nausea during pregnancy (NP) was graded in eight levels of « severity » based on its onset, frequency, and duration.
Level 1, the most severe NP, was associated with a lower risk for a congenital heart defect in the child (odds ratio (OR)=0.81,95% confidence interval (Cl) 0.67-0.99) compared with no nausea.
The lower risk tended to disappear with less severe levels of nausea, and the trend was statistically significant.
Overall, early NP (levels 1 to 4 combined) with use of antinausea medication, particularly Bendectin (doxylamine, dicyclomine (dropped from the formulation in 1976), pyridoxine (vitamin B6)), was associated with a lower risk for congenital heart defects compared with : 1) absence of nausea (OR=0.67,95% Cl 0.50-0.92), and 2) nausea without medication use (OR=0.70,95% Cl 0.50-0.94).
The results suggest that pregnancy hormones and factors or, alternatively, a component of Bendectin (most probably pyridoxine) may be important for normal heart development.
These findings outline potential areas for future research on and prevention of congenital heart defects.
Mots-clés Pascal : Cardiopathie, Congénital, Gestation, Nausée, Pyridoxine, Antiémétique, Epidémiologie, Facteur risque, Homme, Femelle, Etude cas témoin, Toxicité, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Maladie congénitale
Mots-clés Pascal anglais : Heart disease, Congenital, Pregnancy, Nausea, Pyridoxine, Antiemetic, Epidemiology, Risk factor, Human, Female, Case control study, Toxicity, United States, North America, America, Cardiovascular disease, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0229129
Code Inist : 002B02U10. Création : 16/11/1999.