logo BDSP

Base documentaire


  1. Risk of venous thromboembolism associated with the common hereditary haemochromatosis Hfe gene (C282Y) mutation.

    Article - En anglais

    A high prevalence of a common mutation in the Hfe gene (C282Y) has recently been reported in patients with the factor V Leiden mutation and a history of thrombosis.

    The aim of this study was to estimate the relative risk of venous thromboembolism in a large case-control study. 56/481 patients (11.6%) and 57/497 controls (11.5%) were heterozygous for the C282Y allele giving an odds ratio of 1.02 (95% CI 0.69-1.51). 12/81 patients with the factor V Leiden mutation were heterozygous for the C282Y allele compared to 1/13 controls, odds ratio 2.09 (95% CI 0.25-17.6).

    An analysis of a further group of patients and controls selected for the factor V Leiden mutation did not indicate a higher prevalence of the C282Y allele in symptomatic patients, odds ratio 0.17 (95% CI 0.34-0.81).

    This study does not support the hypothesis that the C282Y allele is an additional risk factor for venous thrombosis in patients with the factor V Leiden mutation.

    Mots-clés Pascal : Thrombose, Veine, Thromboembolie, Hémochromatose, Facteur V Leiden, Mutation, Gène, Facteur risque, Epidémiologie, Etude cas témoin, Canada, Amérique du Nord, Amérique, Homme, Fer, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Maladie héréditaire, Métabolisme pathologie, Enzymopathie, Génétique, Gène Hfe

    Mots-clés Pascal anglais : Thrombosis, Vein, Thromboembolism, Hemochromatosis, Factor V Leiden, Mutation, Gene, Risk factor, Epidemiology, Case control study, Canada, North America, America, Human, Iron, Cardiovascular disease, Vascular disease, Venous disease, Genetic disease, Metabolic diseases, Enzymopathy, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0227319

    Code Inist : 002B12B03. Création : 16/11/1999.