Occupational solvent exposure may increase the risk of connective tissue disease (CTD).
The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio.
Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for any CTD but had at least two documented signs, symptoms, or laboratory abnormalities suggestive of a CTD.
Detailed information on solvent exposure was ascertained from 205 cases, diagnosed between 1980 and 1992, and 2,095 population-based controls.
Age-adjusted odds ratios (OR) and 95 percent confidence intervals (Cl) were calculated for all exposures.
Among 16 self-reported occupational activities with potential solvent exposure, furniture refinishing (OR=9.73,95 percent Cl 1.48-63.90), perfume, cosmetic, or drug manufacturing (OR=7.71,95 percent Cl 2.24-26.56), rubber product manufacturing (OR=4.70,95 percent Cl 1.75-12.61), work in a medical diagnostic or pathology laboratory (OR=4.52,95 percent Cl 2.27-8.97), and painting or paint manufacturing (OR=2.87,95 percent Cl 1.06-7.76) were significantly associated with UCTD.
After expert review of self-reported exposure to ten specific solvents, paint thinners or removers (OR=2.73,95 percent Cl 1.80-4.16) and mineral spirits (OR=1.81,95 percent Cl 1.09-3.02) were associated with UCTD. (...)
Mots-clés Pascal : Tissu conjonctif pathologie, Exposition professionnelle, Produit pétrolier, Solvant, Santé et environnement, Epidémiologie, Facteur risque, Homme, Michigan, Etats Unis, Amérique du Nord, Amérique, Ohio, Toxicité, Peau pathologie, Médecine travail
Mots-clés Pascal anglais : Connective tissue disease, Occupational exposure, Petroleum product, Solvent, Health and environment, Epidemiology, Risk factor, Human, Michigan, United States, North America, America, Ohio, Toxicity, Skin disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0226528
Code Inist : 002B03L04. Création : 16/11/1999.