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  1. Diagnosis and treatment of cervical intraepithelial neoplasia grade 3 : a registry-based study in the Romagna region of Italy (1986-1993).

    Article - En anglais

    Background Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) is one of the most unexplored issues of the monitoring of cervical cancer screening.

    We evaluated (1) the frequency of major patterns of diagnosis and treatment of CIN3 (ICD-O code 8070.2), (2) the determinants of hysterectomy as a first choice treatment, and (3) the determinants of invasive cervical squamous carcinoma (CSC) detection among CIN3 cases treated by hysterectomy.

    Methods A population-based, retrospective, descriptive (objective 1) and analytical (objectives 2 and 3) study was conducted by the Romagna Cancer Registry (Northern Italy).

    Included were 316 CIN3 patients (median age, 38.5 years ; range, 21-80) registered between 1986 and 1993 and meeting one of the following eligibility criteria : histological diagnosis of CIN3 on biopsy with any subsequent treatment, histological diagnosis of CIN3 on conization, histological diagnosis of CIN3 on hysterectomy with previous negative/benign (<=CIN2) biopsy or conization.

    Multivariate associations were evaluated by the multiple logistic regression.

    Results Of 316 patients, 264 (84%) were first diagnosed on biopsy, 39 (12%) on conization, and 13 (4%) on hysterectomy.

    Among the 264 patients diagnosed on biopsy, the first choice treatment was local destructive therapy for 16 (6%), conization for 155 (59%) and hysterectomy for 93 (35%). (...)

    Mots-clés Pascal : Tumeur maligne, Col utérus, Grade histologique, Invasion épithéliale, Diagnostic, Traitement, Chirurgie, Hystérectomie, Enregistrement donnée, Choix, Homme, Femelle, Registre, Epidémiologie, Italie, Europe, Appareil génital femelle pathologie, Col utérus pathologie

    Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Histological grading, Epithelial downgrowth, Diagnosis, Treatment, Surgery, Hysterectomy, Data logging, Choice, Human, Female, Register, Epidemiology, Italy, Europe, Female genital diseases, Uterine cervix diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0223019

    Code Inist : 002B20C02. Création : 16/11/1999.