Background Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) is one of the most unexplored issues of the monitoring of cervical cancer screening.
We evaluated (1) the frequency of major patterns of diagnosis and treatment of CIN3 (ICD-O code 8070.2), (2) the determinants of hysterectomy as a first choice treatment, and (3) the determinants of invasive cervical squamous carcinoma (CSC) detection among CIN3 cases treated by hysterectomy.
Methods A population-based, retrospective, descriptive (objective 1) and analytical (objectives 2 and 3) study was conducted by the Romagna Cancer Registry (Northern Italy).
Included were 316 CIN3 patients (median age, 38.5 years ; range, 21-80) registered between 1986 and 1993 and meeting one of the following eligibility criteria : histological diagnosis of CIN3 on biopsy with any subsequent treatment, histological diagnosis of CIN3 on conization, histological diagnosis of CIN3 on hysterectomy with previous negative/benign (<=CIN2) biopsy or conization.
Multivariate associations were evaluated by the multiple logistic regression.
Results Of 316 patients, 264 (84%) were first diagnosed on biopsy, 39 (12%) on conization, and 13 (4%) on hysterectomy.
Among the 264 patients diagnosed on biopsy, the first choice treatment was local destructive therapy for 16 (6%), conization for 155 (59%) and hysterectomy for 93 (35%). (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Grade histologique, Invasion épithéliale, Diagnostic, Traitement, Chirurgie, Hystérectomie, Enregistrement donnée, Choix, Homme, Femelle, Registre, Epidémiologie, Italie, Europe, Appareil génital femelle pathologie, Col utérus pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Histological grading, Epithelial downgrowth, Diagnosis, Treatment, Surgery, Hysterectomy, Data logging, Choice, Human, Female, Register, Epidemiology, Italy, Europe, Female genital diseases, Uterine cervix diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0223019
Code Inist : 002B20C02. Création : 16/11/1999.