Background Previous studies from Africa have suggested that there is little benefit to be gained from early two-dose measles vaccination schedules.
Two-dose schedules have been associated with no improvement in coverage due to immunization of the same individuals on both occasions, low return rate, high refusal rate, low vaccine efficacy, and fear of blunting of the antibody response.
Because of the poor results achieved previously with two-dose measles vaccination schedules, we studied patterns of participation, reasons for non-participation, vaccination coverage and relative efficacy of a one-dose versus a two-dose schedule in connection with the implementation of an early two-dose trial in Guinea-Bissau.
Methods Children born from September 1994 to January 1996 were randomized into two groups receiving either two doses of measles vaccine at 6 and 9 months or one dose of inactivated polio vaccine (IPV) at 6 months and measles vaccine at 9 months.
Results At 6 months of age 86% (1869/2181) of the children participated, and at 9 months of age participation was 87% (1775/2035).
The return rate for obtaining a second dose of vaccine was 93% (1647/1773).
The main reason for not participating was travelling (78%). Around 50% of those who did not take part in one vaccination took part in the other. (...)
Mots-clés Pascal : Vaccination, Rougeole, Virose, Infection, Dose répétée, Précoce, Epidémiologie, Evaluation, Efficacité, Nourrisson, Homme, Prévention, Guinée Bissau, Afrique, Participation, Taux
Mots-clés Pascal anglais : Vaccination, Measles, Viral disease, Infection, Multiple dose, Early, Epidemiology, Evaluation, Efficiency, Infant, Human, Prevention, Guinea-Bissau, Africa, Participation, Rate
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0223016
Code Inist : 002B05A02. Création : 16/11/1999.