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  1. Variation in blood concentrations of cadmium and lead in the elderly.

    Article - En anglais

    This study aims at characterizing blood concentrations of cadmium (B-Cd) and lead (B-Pb) in a group of 176 men and 248 women, 49-92 years of age (mean 68 years), selected from the Swedish Twin Registry.

    Metal concentrations were determined using graphite furnace atomic absorption spectrophotometry.

    B-Cd ranged from 0.05 to 6.8 mug Cd/L (median 0.36 mug Cd/L) and B-Pb from 5.6 to 150 mug Pb/L (median 27 mug Pb/L).

    As expected, smokers had higher B-Cd than nonsmokers (median 1.3 versus 0.32 mug Cd/L), while B-Pb was not significantly related to smoking habits.

    Among nonsmokers, women had higher B-Cd than men (median 0.35 versus 0.25 mug Cd/L).

    In men, but not women, B-Cd increased with age and consequently the gender-related difference in B-Cd was most obvious in the youngest age group.

    On the other hand, women had lower B-Pb than men (median 24 versus 30 mug Pb/L).

    In both men and women, B-Pb decreased between 50 and 70 years of age, perhaps reflecting decreased energy intake.

    In women, the highest B-Pb in the 50-55 years age group is probably related to an increased release of Pb from the skeleton during postmenopausal bone demineralization.

    After about 70 years, B-Pb tended to increase, which probably is a cohort effect due to much higher Pb exposure 10-30 years ago when leaded gasoline was used.

    Mots-clés Pascal : Cadmium, Comparaison interindividuelle, Plomb, Métal lourd, Liquide biologique, Taux, Sang, Homme, Age, Sexe, Exposition professionnelle, Fumeur, Non fumeur, Epidémiologie, Suède, Europe, Personne âgée

    Mots-clés Pascal anglais : Cadmium, Interindividual comparison, Lead, Heavy metal, Biological fluid, Rate, Blood, Human, Age, Sex, Occupational exposure, Smoker, Non smoker, Epidemiology, Sweden, Europe, Elderly

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0222755

    Code Inist : 002B03L05. Création : 16/11/1999.