This study aims at characterizing blood concentrations of cadmium (B-Cd) and lead (B-Pb) in a group of 176 men and 248 women, 49-92 years of age (mean 68 years), selected from the Swedish Twin Registry.
Metal concentrations were determined using graphite furnace atomic absorption spectrophotometry.
B-Cd ranged from 0.05 to 6.8 mug Cd/L (median 0.36 mug Cd/L) and B-Pb from 5.6 to 150 mug Pb/L (median 27 mug Pb/L).
As expected, smokers had higher B-Cd than nonsmokers (median 1.3 versus 0.32 mug Cd/L), while B-Pb was not significantly related to smoking habits.
Among nonsmokers, women had higher B-Cd than men (median 0.35 versus 0.25 mug Cd/L).
In men, but not women, B-Cd increased with age and consequently the gender-related difference in B-Cd was most obvious in the youngest age group.
On the other hand, women had lower B-Pb than men (median 24 versus 30 mug Pb/L).
In both men and women, B-Pb decreased between 50 and 70 years of age, perhaps reflecting decreased energy intake.
In women, the highest B-Pb in the 50-55 years age group is probably related to an increased release of Pb from the skeleton during postmenopausal bone demineralization.
After about 70 years, B-Pb tended to increase, which probably is a cohort effect due to much higher Pb exposure 10-30 years ago when leaded gasoline was used.
Mots-clés Pascal : Cadmium, Comparaison interindividuelle, Plomb, Métal lourd, Liquide biologique, Taux, Sang, Homme, Age, Sexe, Exposition professionnelle, Fumeur, Non fumeur, Epidémiologie, Suède, Europe, Personne âgée
Mots-clés Pascal anglais : Cadmium, Interindividual comparison, Lead, Heavy metal, Biological fluid, Rate, Blood, Human, Age, Sex, Occupational exposure, Smoker, Non smoker, Epidemiology, Sweden, Europe, Elderly
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0222755
Code Inist : 002B03L05. Création : 16/11/1999.