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  1. A community outbreak of Legionnaires'disease linked to hospital cooling towers : an epidemiological method to calculate dose of exposure.

    Article - En anglais

    Background From July to September 1994,29 cases of community-acquired Legionnaires'disease (LD) were reported in Delaware.

    The authors conducted an investigation to a) identify the source of the outbreak and risk factors for developing Legionella pneumophila serogroup 1 (Lp-1) pneumonia and b) evaluate the risk associated with the components of cumulative exposure to the source (i.e. distance from the source, frequency of exposure, and duration of exposure).

    Methods A case-control study matched 21 patients to three controls per case by known risk factors for acquiring LD.

    Controls were selected from patients who attended the same clinic as the respective case-patients.

    Water samples taken at the hospital, from eight nearby cooling towers, and from four of the patient's homes were cultured for Legionella.

    Isolates were subtyped using monoclonal antibody (Mab) analysis and arbitrarily primed polymerase chain reaction (AP-PCR).

    Results Eleven (52%) of 21 case-patients worked at or visited the hospital compared with 17 (27%) of 63 controls (OR 5.0,95% CI : 1.1-29).

    For those who lived, worked, or visited within 4 square miles of the hospital, the risk of illness decreased by 20% for each 0.10 mile from the hospital ; it increased by 80% for each visit to the hospital ; and it increased by 8% for each hour spent within 0.125 miles of the hospital.

    Lp-1 was isolated from three patients and both hospital cooling towers. (...)

    Mots-clés Pascal : Maladie des légionnaires, Légionellose, Bactériose, Infection, Hospitalisation, Exposition, Contamination, Source, Pollution intérieur, Epidémiologie, Facteur risque, Homme, Santé et environnement, Delaware, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Poumon pathologie, Pneumonie

    Mots-clés Pascal anglais : Legionnaires disease, Legionellosis, Bacteriosis, Infection, Hospitalization, Exposure, Contamination, Source, Indoor pollution, Epidemiology, Risk factor, Human, Health and environment, Delaware, United States, North America, America, Respiratory disease, Lung disease, Pneumonia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0222613

    Code Inist : 002B05B02E. Création : 16/11/1999.