Background Measles is an important public health problem in developing nations and there is concern that immune response to measles vaccination may be compromised by paediatric human immunodeficiency virus (HIV) infection.
Therefore, this study investigated the relationship of immunoglobulin-G (Ig-G) antibody levels in children vaccinated against measles and HIV-1 infection.
Further analysis was done to assess the influence of nutritional status on this relationship Methods The authors measured HIV and measles antibodies in 243 vaccinated children aged 17-41 months from Kampala, Uganda.
Children were from paediatric and HIV clinics.
Potential confounders of this relationship included nutritional anthropometric measures, age at and time since vaccination, measles exposure, family crowding, vaccination clinic and gender.
Univariable and multivariable analyses were used to study these associations.
Results Fifty children (21%) were HIV infected.
In univariable analysis, low measles antibody (<15 ELISA units/ml) was associated with HIV (P=0.05 ; odds ratio (OR)=1.86) and stunting (P=0.06 ; OR=1.68).
Stunting, measured as height-for-age and defined as<-2 standard deviations of the reference population median, was a surrogate for chronic malnutrition.
HIV was strongly associated with stunting (P=0.0001 ; OR=6.62).
In multiple logistic regression, HIV was not associated with low measles antibodies ; however, stunting (P=0.04 ; OR=1.81), and<3 children in the home (P=0. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Rougeole, Vaccination, Immunisation, IgG, Concentration, Plasma sanguin, Epidémiologie, Evaluation, Efficacité, Enfant, Homme, Prévention, Ouganda, Afrique, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Measles, Vaccination, Immunization, IgG, Concentration, Blood plasma, Epidemiology, Evaluation, Efficiency, Child, Human, Prevention, Uganda, Africa, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0222612
Code Inist : 002B05C02D. Création : 16/11/1999.