Lipid peroxidation in workers exposed to hexavalent chromium.
The aim of this study was to investigate whether exposure to hexavalent chromium induces lipid peroxidation in human.
This study involved 25 chrome-plating factory workers and a reference group of 28 control subjects.
The whole-blood and urinary chromium concentrations were determined by graphite furnace atomic absorption spectrophotometry.
Malondialdehyde (MDA), the product of lipid peroxidation, was determined by high-performance liquid chromatography, and the activities of protective enzymes were measured by ultraviolet-visible spectrophotometry.
In the chrome-plating workers, the mean concentrations of chromium in blood and urine were 5.98 mug/L and 5.25 mug/g creatinine, respectively ; the mean concentrations of MDA in blood and urine were 1.7 mumol/L and 2.24 mumol/g creatinine.
The concentrations of both chromium and MDA in blood and urine were significantly higher in the chromium-exposed workers.
The activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) were not markedly different between control and exposed workers.
Data suggest that MDA may be used as a biomarker for occupational chromium exposure.
Antioxidant enzymic activities are not a suitable marker for chromium exposure.
Mots-clés Pascal : Toxicité, Homme, Chrome VI Composé, Métal hexavalent Composé, Métal lourd, Exposition professionnelle, Médecine travail, Industrie métallurgique, Chine, Asie, Peroxydation, Oxydation, Lipide, Antioxydant, Activité enzymatique, Superoxide dismutase, Oxidoreductases, Enzyme, Glutathione peroxidase, Peroxidases, Catalase
Mots-clés Pascal anglais : Toxicity, Human, Chromium VI Compounds, Hexavalent metal Compounds, Heavy metal, Occupational exposure, Occupational medicine, Metallurgical industry, China, Asia, Peroxidation, Oxidation, Lipids, Antioxidant, Enzymatic activity, Superoxide dismutase, Oxidoreductases, Enzyme, Glutathione peroxidase, Peroxidases, Catalase
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0222550
Code Inist : 002B03L05. Création : 16/11/1999.