Objective To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV.
Setting Teaching hospital in Harare, Zimbabwe.
Subjects A bo of 41/2 years and his mother.
Main outcome measures Results of clinical and laboratory investigations.
Results Two weeks after receiving the second dose of ora l poliomyelitis vacci duri nationa l immunisation days the child developed paralysis of the right leg.
He had a high titre of antibodies against poliovirus type 2, as well as antibodies against HIV-1, a low CD4 count, a ratio of CD4 to CD8 coun of 0.47, and hypergammaglobulinaemia.
He did not have any antibodies against diphtheria, tetanus, o poliovirus types I and 3, although he had been given diphtheria, tetanus, and pertussis and oral polio vaccines during his first year and a booster of the diphtheria, tetanus, and pertussis vaccine at 24 months.
He had no clinical symptoms of AIDS, but his mother had AIDS and tuberculosis.
Conclusion Paralytic poliomyelitis in this child with HIV infection was caused by poliovirus type 2 after ora l poliomyelitis vaccine.
Mots-clés Pascal : Paralysie, Poliomyélite antérieure, Virose, Infection, Effet secondaire, Vaccination, Poliovirus, Enterovirus, Picornaviridae, Virus, Voie orale, SIDA, Virus immunodéficience humaine, Lentivirus, Retroviridae, Association, Enfant, Homme, Etude cas, Zimbabwe, Afrique, Système nerveux pathologie, Trouble moteur, Immunoprophylaxie, Toxicologie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Paralysis, Acute anterior poliomyelitis, Viral disease, Infection, Secondary effect, Vaccination, Poliovirus, Enterovirus, Picornaviridae, Virus, Oral administration, AIDS, Human immunodeficiency virus, Lentivirus, Retroviridae, Association, Child, Human, Case study, Zimbabwe, Africa, Nervous system diseases, Motor system disorder, Immunoprophylaxis, Toxicology, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0220644
Code Inist : 002B02U01. Création : 16/11/1999.