A persistent inflammatory response accompanying chronic infections may contribute to the risk of coronary atherothrombosis.
Recent studies have reported an association between chronic respiratory infections and an increased risk of coronary heart disease ; however, these reports have not accounted for important confounders such as impaired lung function.
We considered chronic cough as an indicator of chronic lung infection or inflammation in the original Framingham Heart Study participants aged 47 to 89 years.
Chronic cough was defined as a cough present for at least 3 months in the preceding year and was categorized as either nonproductive or productive.
The association of chronic cough with myocardial infarction was examined for six consecutive examination cycles (1965 to 1979) among participants free of myocardial infarction at the baseline examination.
In a secondary analysis, plasma fibrinogen levels were measured during examination cycle 10 (1965 to 1967) in a subgroup of the study sample (n=1,288).
Multivariable logistic regression analysis was performed adjusting for age, gender, smoking status, forced vital capacity, and other known risk factors.
The cross-sectional pooling method yielded 15,656 person-examinations in 3,637 subjects.
I) uring follow-up, there were 291 incident myocardial infarctions.
Chronic nonproductive cough (odds ratio [OR] 1.8,95% confidence interval [CI] I. 1 to 2.8) and chronic productive cough (OR 1. (...)
Mots-clés Pascal : Toux, Chronique, Facteur risque, Infarctus, Myocarde, Etude longitudinale, Méthodologie, Analyse statistique, Métaanalyse, Prévalence, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Cough, Chronic, Risk factor, Infarct, Myocardium, Follow up study, Methodology, Statistical analysis, Metaanalysis, Prevalence, Human, United States, North America, America, Respiratory disease, Cardiovascular disease, Coronary heart disease, Myocardial disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0220401
Code Inist : 002B11D. Création : 16/11/1999.