To examine the effects of cigarette smoking and smoking cessation on the risk of hip fracture in women.
We studied 116,229 female nurses, 34 to 59 years of age at baseline in 1980, who were followed for up to 12 years.
Smoking habits and the occurrence of incident hip fractures (n=377) due to low or moderate trauma were self-reported on biennial mailed questionnaires.
Compared with women who had never smoked, the age-adjusted relative risk (RR) of hip fracture among current smokers was 1.3 (95% confidence interval [CI 1.0 to 1.7).
The risk of hip fracture increased linearly (P=0.09) with greater cigarette consumption (RR=1.6,95% CI 1.1 to 2.3 for 25 or more cigarettes per day).
These associations were somewhat reduced by adjusting for other risk factors for osteoporosis (menopausal status, use of postmenopausal estrogen, physical activity, and intakes of calcium, alcohol, and caffeine) : RR=1.2,95% CI 0.8 to 1.3 for all current smokers ; RR=1.4,95% Cl 0.9 to 2. for 25 or more cigarettes per day.
Relative risks were further reduced when body mass index was added to the model.
There was no apparent benefit from quitting smoking until 10 years after cessation.
After 10 years, former smokers had a reduced risk of hip fracture (adjusted RR=0.7,95% Cl 0.5 to 0.9) compared with current smokers.
Smokers are at increased risk of hip fracture and their risk rises with greater cigarette consumption. (...)
Mots-clés Pascal : Tabagisme, Etude longitudinale, Facteur risque, Fracture intertrochantérienne, Fémur, Etude comparative, Sevrage, Incidence, Questionnaire, Critère âge, Femelle, Homme, Etats Unis, Amérique du Nord, Amérique, Os, Toxicologie, Prévention, Système ostéoarticulaire pathologie, Traumatisme
Mots-clés Pascal anglais : Tobacco smoking, Follow up study, Risk factor, Intertrochanteric fracture, Femur, Comparative study, Weaning, Incidence, Questionnaire, Age criterion, Female, Human, United States, North America, America, Bone, Toxicology, Prevention, Diseases of the osteoarticular system, Trauma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0219159
Code Inist : 002B03E. Création : 16/11/1999.