The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre-and perimenopausal women.
To determine whether Caucasian women ages 28-48 years with newly defined osteoarthritis (OA) would have greater bone mineral density (BMD) and less bone turnover over time than would women without OA.
Data were derived from the longitudinal Michigan Bone Health Study.
Period prevalence and 3-year incidence of OA were based on radiographs of the dominant hand and both knees, scored with the Kellgren/Lawrence (K/L) scale.
OA scores were related to BMD, which was measured by dual-energy x-ray absorptiometry, and to serum osteocalcin levels, which were measured by radioimmunoassay.
The period prevalence of OA (K/L grade >=2 in the knees or the dominant hand) was 15.3% (92 of 601), with 8.7% for the knees and 6.7% for the hand.
The 3-year incidence of knee OA was 1.9% (9 of 482) and of hand OA was 3.3% (16 of 482).
Women with incident knee OA had greater average BMD (z-scores 0.3-0.8 higher for the 3 BMD sites) than women without knee OA (P<0.04 at the femoral neck).
Women with incident knee OA had less change in their average BMD z-scores over the 3-year study period.
Average BMD z-scores for women with prevalent knee OA were greater (0.4-0.7 higher) than for women without knee OA (P<0.002 at all sites).
There was no difference in average BMD z-scores or their change in women with and without hand OA.
Average serum osteocalcin levels were lower in incident cases of hand OA (>60% ; P=0.02) or knee OA (20% ; P not significant). (...)
Mots-clés Pascal : Arthrose, Articulation, Exploration, Remodelage osseux, Densité, Os, Radiographie, Ostéocalcine, Sérum, Spectrométrie absorption RX, Ménopause, Préménopause, Epidémiologie, Femelle, Adulte, Homme, Main, Genou, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Radiodiagnostic, Exploration radiologique
Mots-clés Pascal anglais : Osteoarthritis, Joint, Exploration, Bone remodeling, Density, Bone, Radiography, Osteocalcin, Serum, X ray absorption spectrometry, Menopause, Premenopause, Epidemiology, Female, Adult, Human, Hand, Knee, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Radiodiagnosis, Radiologic investigation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0218585
Code Inist : 002B15E. Création : 16/11/1999.