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  1. Dna-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit : Is there a relation with the low risk of cardiovascular disease in the Inuit ?

    Article - En anglais

    Greenland Inuit are a population with a low risk of cardiovascular disease.

    Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins. fibrinogen, factor V. glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared with Caucasian populations.

    We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue-type plasminogen activator (t-PA plasminogen activator inhibitor-1 (PAI-1), angiotensin-converting enzyme (ACE) and angiotensinogen in a group of 133 Greenland Inuit, aged 30-34 y. In addition, we compared the plasma levels of these factors and those of C-reactive protein (CRP) and D-Dimer in Inuit and in Danes, comparable for age and gender.

    Frequencies (f) were assessed of the alleles that are known as the potential high risk alleles in Caucasians.

    In the Inuit, the f (insertion allele) of the t-PA intron8ins311 polymorphism was 0.37 (Cl 0.32-0.43), the f (4G allele) of the PAI-promoter polymorphism was 0.88 (Cl 0.83-0.91), the f (deletion allele) of the ACE intron16ins287 polymorphism was 0.40 (CI 0.33-0.47) and the f (M-allele) of the angiotensinogen M/T353 polymorphism was 0.30 (Cl 0.25-0.38).

    As for fibrinogen and FVII polymorphisms. these frequencies are all significantly different from what is reported for Caucasian populations. (...)

    Mots-clés Pascal : Appareil circulatoire pathologie, Facteur risque, Epidémiologie, Variabilité génétique, Polymorphisme, Gène, t-Plasminogen activator, Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Inhibiteur plasminogen activator 1, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Angiotensinogène, Fibrinogène, Facteur coagulation, Dimère D, Pression artérielle, Amérindien, Groenland, Amérique du Nord, Amérique, Ethnie, Homme, Génétique, Prohormone, Système renin angiotensine

    Mots-clés Pascal anglais : Cardiovascular disease, Risk factor, Epidemiology, Genetic variability, Polymorphism, Gene, t-Plasminogen activator, Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Plasminogen activator inhibitor 1, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Angiotensinogen, Fibrinogen, Coagulation factor, D dimer, Arterial pressure, Amerindian, Greenland, North America, America, Ethnic group, Human, Genetics, Prohormone, Renin angiotensin system

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0217856

    Code Inist : 002B12A03. Création : 16/11/1999.