Type II (non-insulin-dependent) diabetes mellitus has a substantial genetic component ; however, its molecular basis remains largely unknown.
The mode of inheritance is likely to be polygenic, with penetrance influenced by environmental factors.
Although the familial aggregation of Type II diabetes is acknowledged, there is little data concerning the prevalence of diabetes in the relatives of subjects with diabetes in comparison with the general population, and our objective was to address this question in the defined geographic region of Oxfordshire, England.
We studied 139 first degree relatives of 90 probands with Type II diabetes who attended routine diabetes clinics in Oxfordshire and documented the fasting plasma glucose, triglyceride and HDL-cholesterol concentrations and BMI of these subjects.
The probands were selected without regard to family history of diabetes.
The control population data were derived from two large-scale Oxford community studies which documented the prevalences of known and newly diagnosed diabetes.
The prevalences of newly diagnosed and known diabetes were calculated for each group.
The mean BMI, and concentrations of fasting glucose, triglyceride and HDL-cholesterol were compared and prevalence ratios for obesity (defined as BMI>30 kg/m2), hyperglycaemia (defined as fasting plasma glucose >= 6.1 mmol/l), and dyslipidaemia (defined as triglyceride>2.0 mmol/l, HDL<1.0 mmol/l) were calculated. (...)
Mots-clés Pascal : Dyslipémie, Hyperglycémie, Epidémiologie, Facteur risque, Génétique, Diabète non insulinodépendant, Obésité, Endocrinopathie, Trouble métabolisme, Homme, Angleterre, Grande Bretagne, Royaume Uni, Europe
Mots-clés Pascal anglais : Dyslipemia, Hyperglycemia, Epidemiology, Risk factor, Genetics, Non insulin dependent diabetes, Obesity, Endocrinopathy, Metabolic disorder, Human, England, Great Britain, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0217778
Code Inist : 002B21E01B. Création : 16/11/1999.