Smoking and oral contraceptives as risk factors for cervical carcinoma in situ.
Human papillomavirus (HPV) is probably a necessary but definitely not a sufficient cause of cervical carcinoma.
However, it remains unclear which factors, in addition to HPV, are important for the development of cervical carcinoma and its precursor lesions.
To address this issue, we conducted a case-control study nested in a population-based cohort consisting of women participating in cytological screening in one Swedish county, any time during 1969 through 1995.
Detailed information on sexual practice, smoking habits and oral contraceptive (OC) use were collected through telephone interviews with 422 case patients diagnosed with cervical carcinoma in situ and 422 control subjects.
All cytological smears were analyzed for presence of HPV16/18 by a polymerase chain reaction (PCR) - based method.
Odds ratios (OR) were used as measures of relative risk.
After multivariate adjustment, a 2-fold higher risk was observed among current smokers compared with never smokers [OR 1.94 ; 95% confidence interval (Cl 1.32-2.85) ], an association apparently confined to women younger than 45 years.
Current use of OCs was associated with a 4-fold increased risk overall (OR 3.64 ; 95% Cl 1.91-6.93) with a monotonic increase with increasing duration of use (p for trend<0.001).
The number of sexual partners was significantly, positively associated with risk among HPV 16/18-negative (p for trend<0.005) but not among HPV 16/18-positive women. (...)
Mots-clés Pascal : Carcinome, Col utérus, Cancer in situ, Contraceptif, Voie orale, Tabagisme, Facteur risque, Epidémiologie, Etude cas témoin, Suède, Europe, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Carcinoma in situ, Contraceptive, Oral administration, Tobacco smoking, Risk factor, Epidemiology, Case control study, Sweden, Europe, Human, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0214777
Code Inist : 002B20C02. Création : 16/11/1999.