Arterial endothelial dysfunction related to passive smoking is potentially reversible in healthy young adults.
Passive smoking is associated with early arterial damage, but the potential for reversibility of this damage is unknown.
To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis.
Academic medical center.
60 healthy persons 15 to 39 years of age : 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to environmental tobacco smoke for>1 hour per day for>2 years), and 20 former passive smokers.
Arterial endothelial function measured by noninvasive ultrasonography.
Endothelium-dependent dilatation was significantly better in former passive smokers (5.1% ± 4.1% [range, - 1.2% to 15.6% ]) than in current passive smokers (2.3% ± 2.1% [range, - 0.2% to 6.7% ]) (P=0.01), although both groups were significantly impaired compared with nonsmoking controls (8.9% ± 3.2% [range, 2.1% to 16.7% ]) (P<0.01 for both comparisons).
In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.
Mots-clés Pascal : Tabagisme passif, Trouble fonctionnel, Endothélium, Artère, Réversibilité, Toxicologie, Partiel, Pollution air, Adulte jeune, Homme, Individu sain, Appareil circulatoire pathologie, Artère pathologie
Mots-clés Pascal anglais : Passive smoking, Dysfunction, Endothelium, Artery, Reversibility, Toxicology, Partial, Air pollution, Young adult, Human, Healthy subject, Cardiovascular disease, Arterial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0214084
Code Inist : 002B03E. Création : 16/11/1999.