Passive smoking is associated with early arterial damage, but the potential for reversibility of this damage is unknown.
To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis.
Academic medical center.
60 healthy persons 15 to 39 years of age : 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to environmental tobacco smoke for>1 hour per day for>2 years), and 20 former passive smokers.
Arterial endothelial function measured by noninvasive ultrasonography.
Endothelium-dependent dilatation was significantly better in former passive smokers (5.1% ± 4.1% [range, - 1.2% to 15.6% ]) than in current passive smokers (2.3% ± 2.1% [range, - 0.2% to 6.7% ]) (P=0.01), although both groups were significantly impaired compared with nonsmoking controls (8.9% ± 3.2% [range, 2.1% to 16.7% ]) (P<0.01 for both comparisons).
In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.
Mots-clés Pascal : Tabagisme passif, Trouble fonctionnel, Endothélium, Artère, Réversibilité, Toxicologie, Partiel, Pollution air, Adulte jeune, Homme, Individu sain, Appareil circulatoire pathologie, Artère pathologie
Mots-clés Pascal anglais : Passive smoking, Dysfunction, Endothelium, Artery, Reversibility, Toxicology, Partial, Air pollution, Young adult, Human, Healthy subject, Cardiovascular disease, Arterial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0214084
Code Inist : 002B03E. Création : 16/11/1999.