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  1. Arterial endothelial dysfunction related to passive smoking is potentially reversible in healthy young adults.

    Article - En anglais

    Background 

    Passive smoking is associated with early arterial damage, but the potential for reversibility of this damage is unknown.

    Objective 

    To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis.

    Design 

    Cross-sectional study.

    Setting 

    Academic medical center.

    Participants 

    60 healthy persons 15 to 39 years of age : 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to environmental tobacco smoke for>1 hour per day for>2 years), and 20 former passive smokers.

    Measurements 

    Arterial endothelial function measured by noninvasive ultrasonography.

    Results 

    Endothelium-dependent dilatation was significantly better in former passive smokers (5.1% ± 4.1% [range, - 1.2% to 15.6% ]) than in current passive smokers (2.3% ± 2.1% [range, - 0.2% to 6.7% ]) (P=0.01), although both groups were significantly impaired compared with nonsmoking controls (8.9% ± 3.2% [range, 2.1% to 16.7% ]) (P<0.01 for both comparisons).

    Conclusions 

    In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.

    Mots-clés Pascal : Tabagisme passif, Trouble fonctionnel, Endothélium, Artère, Réversibilité, Toxicologie, Partiel, Pollution air, Adulte jeune, Homme, Individu sain, Appareil circulatoire pathologie, Artère pathologie

    Mots-clés Pascal anglais : Passive smoking, Dysfunction, Endothelium, Artery, Reversibility, Toxicology, Partial, Air pollution, Young adult, Human, Healthy subject, Cardiovascular disease, Arterial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0214084

    Code Inist : 002B03E. Création : 16/11/1999.