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  1. Geographical clustering of human T-cell lymphotropic virus type i in guadeloupe, an endemic caribbean area.

    Article - En anglais

    Between January 1989 and December 1996,59,426 blood donors from Guadeloupe (French West Indies) were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I).

    Of these, 195 were confirmed as being positive for HTLV-I, yielding an overall prevalence of 0.33% [95% confidence interval (Cl) 0.28-0.38]. On multiple logistic regression analysis, risk factors for HTLV-I were female gender [odds ratio (OR) 1.8 ; CI 1.3-2.4], increasing age (30-39 years, OR 2.2, CI 1.4-3.4 ; 40-49 years, OR 3.1, Cl 2.1-4.7 ; >=50 years, OR 5.6, Cl 3.6-8.6) and positive hepatitis B core antibodies (OR 2.0 ; CI 1.5-2.8).

    HTLV-I seropositivity was also significantly associated with current residence in certain areas, highlighting microgeographic clustering : individuals living along the Atlantic Façade of Guadeloupe, which is a traditional sugar cane plantation area where Africans were brought during slave trading, were at increased risk for HTLV-I infection (OR 1.9 ; CI 1.3-2.7) compared with other areas in Guadeloupe devoted to other activities.

    Our report of HTLV-I cluster identification in Guadeloupe probably reflects both its low spread and its highly intrafamilial restricted transmission within this endemic Caribbean population.

    Mots-clés Pascal : Virose, Infection, Virus HTLV1, Retroviridae, Virus, Prévalence, Epidémiologie, Donneur sang, Répartition géographique, Guadeloupe, Antilles, Amérique Centrale, Amérique, Homme

    Mots-clés Pascal anglais : Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Prevalence, Epidemiology, Blood donor, Geographic distribution, Guadeloupe, West Indies, Central America, America, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0214038

    Code Inist : 002B05C02D. Création : 16/11/1999.