Hexachlorobenzene, an organochlorine compound that accumulates in humans, is widespread throughout the environment.
In this study, we describe the health status of inhabitants of a rural village that surrounds an electrochemical factory characterized by high levels of hexachlorobenzene in the air.
During 1994, we conducted a cross-sectional study of 1 800 inhabitants in the south of Catalonia, Spain, who were older than 14 y of age.
We obtained information on lifestyles and occupational and medical histories via questionnaire.
Self-reported health outcomes were validated against clinical records and cancer registry data.
Serum levels of hexachlorobenzene were very high in males who worked in the electrochemical factory (geometric mean=54.6 ng/ml in randomized participants).
Levels were lower among subjects who had never worked in the electrochemical factory (females, 14.9 ng/ml ; males, 9.0 ng/ml).
Levels of other organochlorine compounds (i.e., 6-hexachlorocyclohexane, 2,2-bis[p-chlorophenyl]-1,1-dichloroethylene) were in the same range found in other communities.
Perceived health, prevalence of self-reported common chronic conditions, and porphyria cutanea tarda, thyroid pathology, Parkinson's disease, cancer, and reproductive outcomes were within the ranges observed in other studies. (...)
Mots-clés Pascal : Benzène dérivé, Organochloré, Toxicité, Santé et environnement, Dose répétée, Dose forte, Homme, Espagne, Europe, Pollution air, Epidémiologie, Etude transversale, Benzène(hexachloro)
Mots-clés Pascal anglais : Benzene derivatives, Organochlorine compounds, Toxicity, Health and environment, Multiple dose, High dose, Human, Spain, Europe, Air pollution, Epidemiology, Cross sectional study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0213539
Code Inist : 002B03M02. Création : 16/11/1999.