logo BDSP

Base documentaire

  1. Health effects of chronic high exposure to hexachlorobenzene in a general population sample.

    Article - En anglais

    Hexachlorobenzene, an organochlorine compound that accumulates in humans, is widespread throughout the environment.

    In this study, we describe the health status of inhabitants of a rural village that surrounds an electrochemical factory characterized by high levels of hexachlorobenzene in the air.

    During 1994, we conducted a cross-sectional study of 1 800 inhabitants in the south of Catalonia, Spain, who were older than 14 y of age.

    We obtained information on lifestyles and occupational and medical histories via questionnaire.

    Self-reported health outcomes were validated against clinical records and cancer registry data.

    Serum levels of hexachlorobenzene were very high in males who worked in the electrochemical factory (geometric mean=54.6 ng/ml in randomized participants).

    Levels were lower among subjects who had never worked in the electrochemical factory (females, 14.9 ng/ml ; males, 9.0 ng/ml).

    Levels of other organochlorine compounds (i.e., 6-hexachlorocyclohexane, 2,2-bis[p-chlorophenyl]-1,1-dichloroethylene) were in the same range found in other communities.

    Perceived health, prevalence of self-reported common chronic conditions, and porphyria cutanea tarda, thyroid pathology, Parkinson's disease, cancer, and reproductive outcomes were within the ranges observed in other studies. (...)

    Mots-clés Pascal : Benzène dérivé, Organochloré, Toxicité, Santé et environnement, Dose répétée, Dose forte, Homme, Espagne, Europe, Pollution air, Epidémiologie, Etude transversale, Benzène(hexachloro)

    Mots-clés Pascal anglais : Benzene derivatives, Organochlorine compounds, Toxicity, Health and environment, Multiple dose, High dose, Human, Spain, Europe, Air pollution, Epidemiology, Cross sectional study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0213539

    Code Inist : 002B03M02. Création : 16/11/1999.